| UniProt/SwissProt ID: | FES_HUMAN |
| Description: | feline sarcoma oncogene [Source:HGNC Symbol;Acc:3657] |
| Location: | chr15 q26.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T409 | DDRHStSSSEQ | PhosphoSitePlus | |
| T595 | KSCREtLPPDL | Pkinase_Tyr | PhosphoSitePlus |
| S67 | AISPDsPISQS | FCH | PhosphoSitePlus |
| Y156 | QAKRKyQEASK | PhosphoSitePlus | |
| Y713 | EADGVyAASGG | Fes | phosphoELM; RegPhos |
| T423 | GGRTPtLEILK | PhosphoSitePlus | |
| Y811 | SFSTIyQELQS | FES | HPRD; RegPhos |
| Y713 | EADGVyAASGG | Pkinase_Tyr | PhosphoSitePlus |
| Y811 | SFSTIyQELQS | Fes | phosphoELM; RegPhos |
| S716 | GVYAAsGGLRQ | Pkinase_Tyr | PhosphoSitePlus |
| S477 | ELLVHsGDFLV | SH2 | PhosphoSitePlus |
| S64 | QSRAIsPDSPI | FCH | PhosphoSitePlus |
| S408 | QDDRHsTSSSE | PhosphoSitePlus | |
| S100 | NSGPLsKLSLL | PhosphoSitePlus | |
| Y614 | RILKQySHPNI | Pkinase_Tyr | PhosphoSitePlus |
| Y811 | SFSTIyQELQS | Pkinase_Tyr | PhosphoSitePlus |
| S373 | QVALCsQAKLQ | PhosphoSitePlus | |
| Y713 | EADGVyAASGG | FES | HPRD; RegPhos |
| T421 | REGGRtPTLEI | PhosphoSitePlus | |
| S411 | RHSTSsSEQER | PhosphoSitePlus | |
| Y713 | EADGVyAASGG | autocatalysis | RegPhos |
| Y734 | PEALNyGRYSS | Pkinase_Tyr | PhosphoSitePlus |
| S410 | DRHSTsSSEQE | PhosphoSitePlus | |
| Y261 | QPEAEyQGFLR | PhosphoSitePlus | |
| S412 | HSTSSsEQERE | PhosphoSitePlus | |
| Dephosphorylation site |
| FES_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000331504 | S78N | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000331504 | A159V | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| FES_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FES_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK3_HUMAN | FES_HUMAN | kinase -> substrate | NetPath |
| FES_HUMAN | IRS1_HUMAN | kinase -> substrate | NetPath |
| JAK1_HUMAN | FES_HUMAN | kinase -> substrate | NetPath |
| FES_HUMAN | BCR_HUMAN | kinase -> substrate | RegPhos |
| FES_HUMAN | FES_HUMAN | kinase -> substrate | RegPhos |
| FES_HUMAN | IRS2_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030155 | regulation of cell adhesion | IMP | biological_process |
| GO:0031410 | cytoplasmic vesicle | IDA | cellular_component |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0060627 | regulation of vesicle-mediated transport | TAS | biological_process |
| GO:2000145 | regulation of cell motility | IMP | biological_process |
| GO:0031234 | extrinsic to internal side of plasma membrane | IDA | cellular_component |
| GO:2000251 | positive regulation of actin cytoskeleton reorgani | IMP | biological_process |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0042127 | regulation of cell proliferation | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0031116 | positive regulation of microtubule polymerization | IMP | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0045639 | positive regulation of myeloid cell differentiatio | IMP | biological_process |
| GO:0010976 | positive regulation of neuron projection developme | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0043304 | regulation of mast cell degranulation | IMP | biological_process |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0008360 | regulation of cell shape | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0034987 | immunoglobulin receptor binding | IDA | molecular_function |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IDA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IDA | molecular_function |
| GO:0045595 | regulation of cell differentiation | IMP | biological_process |
| GO:0035091 | phosphatidylinositol binding | IDA | molecular_function |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA | biological_process |