Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FES_HUMAN
Description:feline sarcoma oncogene [Source:HGNC Symbol;Acc:3657]
Location:chr15 q26.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T409DDRHStSSSEQPhosphoSitePlus
T595KSCREtLPPDLPkinase_TyrPhosphoSitePlus
S67AISPDsPISQSFCHPhosphoSitePlus
Y156QAKRKyQEASKPhosphoSitePlus
Y713EADGVyAASGGFesphosphoELM; RegPhos
T423GGRTPtLEILKPhosphoSitePlus
Y811SFSTIyQELQSFESHPRD; RegPhos
Y713EADGVyAASGGPkinase_TyrPhosphoSitePlus
Y811SFSTIyQELQSFesphosphoELM; RegPhos
S716GVYAAsGGLRQPkinase_TyrPhosphoSitePlus
S477ELLVHsGDFLVSH2PhosphoSitePlus
S64QSRAIsPDSPIFCHPhosphoSitePlus
S408QDDRHsTSSSEPhosphoSitePlus
S100NSGPLsKLSLLPhosphoSitePlus
Y614RILKQySHPNIPkinase_TyrPhosphoSitePlus
Y811SFSTIyQELQSPkinase_TyrPhosphoSitePlus
S373QVALCsQAKLQPhosphoSitePlus
Y713EADGVyAASGGFESHPRD; RegPhos
T421REGGRtPTLEIPhosphoSitePlus
S411RHSTSsSEQERPhosphoSitePlus
Y713EADGVyAASGGautocatalysis RegPhos
Y734PEALNyGRYSSPkinase_TyrPhosphoSitePlus
S410DRHSTsSSEQEPhosphoSitePlus
Y261QPEAEyQGFLRPhosphoSitePlus
S412HSTSSsEQEREPhosphoSitePlus

Dephosphorylation site
FES_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331504S78NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000331504A159VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
FES_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FES_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK3_HUMANFES_HUMANkinase -> substrateNetPath
FES_HUMANIRS1_HUMANkinase -> substrateNetPath
JAK1_HUMANFES_HUMANkinase -> substrateNetPath
FES_HUMANBCR_HUMANkinase -> substrateRegPhos
FES_HUMANFES_HUMANkinase -> substrateRegPhos
FES_HUMANIRS2_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030155regulation of cell adhesionIMPbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0060627regulation of vesicle-mediated transportTASbiological_process
GO:2000145regulation of cell motilityIMPbiological_process
GO:0031234extrinsic to internal side of plasma membraneIDAcellular_component
GO:2000251positive regulation of actin cytoskeleton reorganiIMPbiological_process
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0042127regulation of cell proliferationIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0031116positive regulation of microtubule polymerizationIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0045639positive regulation of myeloid cell differentiatioIMPbiological_process
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0043304regulation of mast cell degranulationIMPbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0034987immunoglobulin receptor bindingIDAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0045595regulation of cell differentiationIMPbiological_process
GO:0035091phosphatidylinositol bindingIDAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process


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