| UniProt/SwissProt ID: | FCG2A_HUMAN |
| Description: | Fc fragment of IgG, low affinity IIa, receptor (CD32) [Source:HGNC Symbol;Acc:3616] |
| Location: | chr1 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y287 | TADGGyMTLNP | SYK | HPRD |
| Y288 | TADGGyMTLNP | BLK | phosphoELM; RegPhos |
| Y280 | ETNNDyETADG | LYN | HPRD |
| Y304 | DDKNIyLTLPP | FYN | RegPhos |
| Y288 | TADGGyMTLNP | PhosphoSitePlus; phosphoELM | |
| Y281 | ETNNDyETADG | Fyn | phosphoELM; RegPhos |
| Y304 | DDKNIyLTLPP | Syk | RegPhos |
| Y288 | TADGGyMTLNP | SYK | phosphoELM; RegPhos |
| T297 | NPRAPtDDDKN | PhosphoSitePlus | |
| Y303 | DDKNIyLTLPP | SYK | HPRD |
| Y303 | DDKNIyLTLPP | FYN | HPRD |
| Y288 | TADGGyMTLNP | LYN | RegPhos |
| Y287 | TADGGyMTLNP | LYN | HPRD |
| T290 | DGGYMtLNPRA | PhosphoSitePlus | |
| Y240 | VVALIyCRKKR | TM | PhosphoSitePlus |
| Y303 | DDKNIyLTLPP | LYN | HPRD |
| Y304 | DDKNIyLTLPP | SYK | phosphoELM; RegPhos |
| Y288 | TADGGyMTLNP | Syk | RegPhos |
| Y281 | ETNNDyETADG | Syk | RegPhos |
| T283 | NNDYEtADGGY | PhosphoSitePlus | |
| Y281 | ETNNDyETADG | Lyn | phosphoELM; RegPhos |
| Y281 | ETNNDyETADG | SYK | phosphoELM; RegPhos |
| Y281 | ETNNDyETADG | LYN | RegPhos |
| Y304 | DDKNIyLTLPP | PhosphoSitePlus | |
| Y304 | DDKNIyLTLPP | Lyn | phosphoELM; RegPhos |
| Y304 | DDKNIyLTLPP | BLK | phosphoELM; RegPhos |
| Y281 | ETNNDyETADG | FYN | RegPhos |
| Y280 | ETNNDyETADG | BLK | HPRD |
| Y303 | DDKNIyLTLPP | BLK | HPRD |
| Y281 | ETNNDyETADG | BLK | phosphoELM; RegPhos |
| Y280 | ETNNDyETADG | SYK | HPRD |
| Y304 | DDKNIyLTLPP | LYN | RegPhos |
| Y288 | TADGGyMTLNP | Fyn | phosphoELM; RegPhos |
| Y288 | TADGGyMTLNP | FYN | RegPhos |
| Y281 | ETNNDyETADG | PhosphoSitePlus | |
| Y287 | TADGGyMTLNP | BLK | HPRD |
| Y304 | DDKNIyLTLPP | Fyn | phosphoELM; RegPhos |
| Y287 | TADGGyMTLNP | FYN | HPRD |
| T277 | RQLEEtNNDYE | PhosphoSitePlus | |
| Y288 | TADGGyMTLNP | Lyn | phosphoELM; RegPhos |
| Y280 | ETNNDyETADG | FYN | HPRD |
| Dephosphorylation site |
| FCG2A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271450 | N178K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356949 | N177K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| FCG2A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FCG2A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LYN_HUMAN | FCG2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| KSYK_HUMAN | FCG2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| FYN_HUMAN | FCG2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| BLK_HUMAN | FCG2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04380 | Osteoclast differentiation |
| hsa05322 | Systemic lupus erythematosus |
| hsa05140 | Leishmaniasis |
| hsa05150 | Staphylococcus aureus infection |
| hsa05152 | Tuberculosis |
| hsa04145 | Phagosome |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019864 | IgG binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |