Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FADD_HUMAN
Description:Fas (TNFRSF6)-associated via death domain [Source:HGNC Symbol;Acc:3573]
Location:chr11 q13.3
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S194RSGAMsPMSWNCK1aRegPhos
S197AMSPMsWNSDAHPRD
T21SSSELtELKFLHPRD
S41LERVQsGLDLFDEDPhosphoSitePlus
Y133SIEDRyPRNLTDUF3631; DeathPhosphoSitePlus
S194RSGAMsPMSWNHIPK3HPRD; phosphoELM; RegPhos
S41LERVQsGLDLFHPRD
S194RSGAMsPMSWNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S190DLQNRsGAMSPDUF3631PhosphoSitePlus
S203WNSDAsTSEASPhosphoSitePlus
S18SSLSSsELTELHPRD
S194RSGAMsPMSWNCSNK1A1HPRD
T157EKENAtVAHLVDUF3631; DeathPhosphoSitePlus

Dephosphorylation site
FADD_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301838R114SCOSMICOvarian Cancer21720365
ENSP00000301838K125NCOSMICPancreatic Cancer
ENSP00000301838R114STCGAOvarian Cancer21720365, 18772890
ENSP00000301838S194FCOSMICLung Cancer20668451

Differential expressed protein
FADD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FADD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK3_HUMANFADD_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFADD_HUMANkinase -> substrateRegPhos
KC1A_HUMANFADD_HUMANkinase -> substrateHPRD
FADD_HUMANCASP8_HUMANotherKEGG
MYD88_HUMANFADD_HUMANotherKEGG
TNR6_HUMANFADD_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa05152Tuberculosis
hsa04210Apoptosis
hsa05142Chagas disease (American trypanosomiasis)
hsa04622RIG-I-like receptor signaling pathway
hsa05200Pathways in cancer
hsa04620Toll-like receptor signaling pathway
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031265CD95 death-inducing signaling complexIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0032813tumor necrosis factor receptor superfamily bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0051607defense response to virusIMPbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0031264death-inducing signaling complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005123death receptor bindingTASmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0032760positive regulation of tumor necrosis factor produIDAbiological_process
GO:0097190apoptotic signaling pathwayIDAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0097191extrinsic apoptotic signaling pathwayIMPbiological_process
GO:0031265CD95 death-inducing signaling complexIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0070265necrotic cell deathIMPbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0043005neuron projectionIEAcellular_component
GO:0044297cell bodyIEAcellular_component
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0060340positive regulation of type I interferon-mediated IMPbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0008625extrinsic apoptotic signaling pathway via death doTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0051291protein heterooligomerizationIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23