| UniProt/SwissProt ID: | ERF1_HUMAN |
| Description: | eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:3477] |
| Location: | chr5 q31.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S23 | KKLIKsLEAAR | eRF1_1 | PhosphoSitePlus |
| T208 | RKVAEtAVQLF | HPRD | |
| T32 | ARGNGtSMISL | eRF1_1 | PhosphoSitePlus |
| S70 | RVNRLsVLGAI | eRF1_1 | PhosphoSitePlus |
| S215 | VQLFIsGDKVN | HPRD | |
| S36 | GTSMIsLIIPP | eRF1_1 | PhosphoSitePlus |
| T208 | RKVAEtAVQLF | eRF1_2 | PhosphoSitePlus |
| S215 | VQLFIsGDKVN | eRF1_2 | PhosphoSitePlus |
| S33 | RGNGTsMISLI | eRF1_1 | PhosphoSitePlus |
| Y201 | EKRHNyVRKVA | eRF1_2 | PhosphoSitePlus |
| Dephosphorylation site |
| ERF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353741 | L126F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353741 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.3 | 18646787 |
| Hyperphosphorylation site |
| ERF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK4_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHA3_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ERF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006415 | translational termination | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006412 | translation | TAS | biological_process |
| GO:0003747 | translation release factor activity | TAS | molecular_function |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0008079 | translation termination factor activity | TAS | molecular_function |
| GO:0016149 | translation release factor activity, codon specifi | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006449 | regulation of translational termination | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0043022 | ribosome binding | TAS | molecular_function |
| GO:0006479 | protein methylation | IDA | biological_process |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsen | TAS | biological_process |