Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHB2_HUMAN
Description:EPH receptor B2 [Source:HGNC Symbol;Acc:3393]
Location:chr1 p36.12
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T775FLEDDtSDPTYPkinase_TyrPhosphoSitePlus
Y585DKLQHyTSGHMHPRD
Y595TPGMKiYIDPFHPRD
S776LEDDTsDPTYTPkinase_TyrPhosphoSitePlus; SysPTM
Y596TPGMKiYIDPFHPRD
S768SDFGLsRFLEDPkinase_TyrPhosphoSitePlus
Y596PGMKIyIDPFTPhosphoSitePlus; HPRD; RegPhos
Y801PEAIQyRKFTSHPRD
Y584DKLQHyTSGHMPhosphoSitePlus; HPRD; RegPhos
Y780DTSDPtYTSALHPRD; SysPTM
Y780TSDPTyTSALGPkinase_TyrPhosphoSitePlus; SysPTM
Y481KELSEyNATAIfn3PhosphoSitePlus
S575FERADsEYTDKPhosphoSitePlus
Y602IDPFTyEDPNEEPHB2HPRD
T775FLEDDtSDPTYphosphoELM; RegPhos
Y175SRSGFyLAFQDEphrin_lbdPhosphoSitePlus
T776FLEDDtSDPTYEPHB2HPRD
Y602YIDPFtYEDPNHPRD
Y659TLKSGyTEKQRHPRD; RegPhos
Y780TSDPTyTSALGHPRD; RegPhos; SysPTM
Y601YIDPFtYEDPNHPRD
T590TSGHMtPGMKIPhosphoSitePlus
S756NILVNsNLVCKPkinase_TyrPhosphoSitePlus
Y930IKMGQyKESFAautocatalysis RegPhos
Y912RTIPDyTSFNTSAM_1PhosphoSitePlus
Y602IDPFTyEDPNEautocatalysis RegPhos
Y577RADSEyTDKLQPhosphoSitePlus; HPRD; RegPhos
Y779DTSDPtYTSALHPRD
Y800PEAIQyRKFTSPkinase_TyrPhosphoSitePlus
Y800PEAIQyRKFTSHPRD; RegPhos
Y742LADMNyVHRDLHPRD; RegPhos
S777LEDDTsDPTYTEPHB2HPRD
Y603IDPFTyEDPNEEPHB2HPRD
Y597PGMKIyIDPFTHPRD
S776LEDDTsDPTYTEPHB2HPRD; SysPTM
T775FLEDDtSDPTYEPHB2HPRD
Y742LADMNyVHRDLPkinase_TyrPhosphoSitePlus
Y736AAGMKyLADMNHPRD; RegPhos
Y602IDPFTyEDPNEEphB2RegPhos
T585KLQHYtSGHMTPhosphoSitePlus
Y737AAGMKyLADMNHPRD
T601YIDPFtYEDPNPhosphoSitePlus
T578ADSEYtDKLQHPhosphoSitePlus
Y602IDPFTyEDPNEPhosphoSitePlus
Y194AVRVFyRKCPREphrin_lbdPhosphoSitePlus
Y181LAFQDyGGCMSEphrin_lbdPhosphoSitePlus
Y780TSDPTyTSALGautocatalysis RegPhos; SysPTM
Y596PGMKIyIDPFTautocatalysis RegPhos
Y930IKMGQyKESFAHPRD; RegPhos
Y931IKMGQyKESFAHPRD
Y660TLKSGyTEKQRHPRD
T779DTSDPtYTSALPkinase_TyrPhosphoSitePlus
Y781TSDPTyTSALGHPRD
S763LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
Y743LADMNyVHRDLHPRD
S148ADESFsQVDLGEphrin_lbdPhosphoSitePlus
Y578RADSEyTDKLQHPRD
S586LQHYTsGHMTPPhosphoSitePlus

Dephosphorylation site
EPHB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000383053V650AHPIProstate Cancer16155194
ENSP00000383053A279SHPIProstate Cancer15300251 16155194 17344846
ENSP00000383053A434SOMIMProstate Cancer15300251
ENSP00000383053I909MHPIProstate Cancer15300251
ENSP00000383053M883VHPIProstate Cancer16155194
ENSP00000383053T22MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363763S426CTCGAOvarian Cancer21720365, 18772890
ENSP00000383053H679NHPIProstate Cancer15300251
ENSP00000383053R199HHPIProstate Cancer15300251

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000383053Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueUp2.219329653

Hyperphosphorylation site
EPHB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB3_HUMANEPHB2_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB2_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHB2_HUMANligand -> receptorHPMR
EPHB2_HUMANEPHB2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANEPHB2_HUMANkinase -> substrateRegPhos
EPHB2_HUMANITB4_HUMANkinase -> substrateNetPath
EPHB2_HUMANRRAS_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007612learningIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007399nervous system developmentTASbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0004713protein tyrosine kinase activityISSmolecular_function
GO:0016310phosphorylationISSbiological_process
GO:0042472inner ear morphogenesisISSbiological_process
GO:0005005transmembrane-ephrin receptor activityISSmolecular_function
GO:0001655urogenital system developmentISSbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0051965positive regulation of synapse assemblyISSbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0071679commissural neuron axon guidanceISSbiological_process
GO:0018108peptidyl-tyrosine phosphorylationISSbiological_process
GO:0008046axon guidance receptor activityIEAmolecular_function
GO:0004872receptor activityIEAmolecular_function
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0022038corpus callosum developmentISSbiological_process
GO:0030425dendriteISScellular_component
GO:0050770regulation of axonogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0021952central nervous system projection neuron axonogeneIEAbiological_process
GO:0021631optic nerve morphogenesisIEAbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0050878regulation of body fluid levelsISSbiological_process
GO:0048593camera-type eye morphogenesisIEAbiological_process
GO:0060996dendritic spine developmentISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0050771negative regulation of axonogenesisIEAbiological_process
GO:0048013ephrin receptor signaling pathwayISSbiological_process
GO:0030424axonISScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001525angiogenesisISSbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0048170positive regulation of long-term neuronal synapticIEAbiological_process
GO:0060997dendritic spine morphogenesisISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007413axonal fasciculationISSbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0060021palate developmentISSbiological_process
GO:0048168regulation of neuronal synaptic plasticityIEAbiological_process


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