| UniProt/SwissProt ID: | EPHA5_HUMAN |
| Description: | EPH receptor A5 [Source:HGNC Symbol;Acc:3389] |
| Location: | chr4 q13.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S960 | LLAEHsPLGSG | PhosphoSitePlus; HPRD | |
| T301 | EEKNGtCQVCR | GCC2_GCC3 | PhosphoSitePlus |
| Y656 | IDPHTyEDPNQ | PhosphoSitePlus | |
| S873 | MWEVVsYGERP | Pkinase_Tyr | PhosphoSitePlus |
| T649 | LPGVRtYIDPH | PhosphoSitePlus | |
| S313 | GFFKAsPHIQS | GCC2_GCC3 | PhosphoSitePlus |
| Y967 | LGSGAyRSVGE | SAM_1 | PhosphoSitePlus |
| Y796 | LSDMGyVHRDL | Pkinase_Tyr | PhosphoSitePlus |
| S938 | LLAEHsPLGSG | HPRD | |
| T856 | AFRKFtSASDV | Pkinase_Tyr | PhosphoSitePlus |
| Y790 | SAGMKyLSDMG | Pkinase_Tyr | PhosphoSitePlus |
| T835 | EAAYTtRGGKI | Pkinase_Tyr | PhosphoSitePlus |
| S942 | HSPLGsGAYRS | HPRD | |
| Y967 | LGSGAyRSVGE | HPRD | |
| Y945 | LGSGAyRSVGE | HPRD | |
| Y650 | PGVRTyIDPHT | PhosphoSitePlus | |
| S964 | HSPLGsGAYRS | PhosphoSitePlus; HPRD | |
| S953 | ASCRVsNLLAE | PhosphoSitePlus | |
| T197 | VMKLNtEVRDV | Ephrin_lbd | PhosphoSitePlus |
| Y833 | DPEAAyTTRGG | Pkinase_Tyr | PhosphoSitePlus |
| Y833 | DPEAAyTTRGG | phosphoELM | |
| Y295 | MCKAGyEEKNG | PhosphoSitePlus; HPRD | |
| S318 | SPHIQsCGKCP | GCC2_GCC3 | PhosphoSitePlus |
| S4 | __MRGsGPRGA | PhosphoSitePlus | |
| S822 | SDFGLsRVLED | Pkinase_Tyr | PhosphoSitePlus |
| Dephosphorylation site |
| EPHA5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000273854 | N1032S | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000273854 | S566Y | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | R417Q | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000273854 | E503K | HPI | Non-small cell lung carcinoma | 17344846 | ENSP00000273854 | R1007Q | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | E503K | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000273854 | S810I | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | N1032S | HPI | Non-small cell lung carcinoma | 17344846 | ENSP00000273854 | D493Y | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | P1036A | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | T856I | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000273854 | M1034I | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000273854 | G582E | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| EPHA5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EPHA5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EFNA3_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| EFNA4_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| EFNA2_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| EFNA5_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| EFNA1_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032314 | regulation of Rac GTPase activity | ISS | biological_process |
| GO:0005005 | transmembrane-ephrin receptor activity | NAS | molecular_function |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0021766 | hippocampus development | IEA | biological_process |
| GO:0005791 | rough endoplasmic reticulum | IDA | cellular_component |
| GO:0061178 | regulation of insulin secretion involved in cellul | ISS | biological_process |
| GO:0030425 | dendrite | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0032314 | regulation of Rac GTPase activity | IEA | biological_process |
| GO:0032956 | regulation of actin cytoskeleton organization | ISS | biological_process |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007411 | axon guidance | ISS | biological_process |
| GO:0043025 | neuronal cell body | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005004 | GPI-linked ephrin receptor activity | ISS | molecular_function |
| GO:0019933 | cAMP-mediated signaling | ISS | biological_process |
| GO:0021766 | hippocampus development | ISS | biological_process |
| GO:0032793 | positive regulation of CREB transcription factor a | ISS | biological_process |
| GO:0048013 | ephrin receptor signaling pathway | ISS | biological_process |
| GO:0005004 | GPI-linked ephrin receptor activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0048013 | ephrin receptor signaling pathway | IEA | biological_process |
| GO:0005003 | ephrin receptor activity | ISS | molecular_function |
| GO:0051964 | negative regulation of synapse assembly | IEA | biological_process |
| GO:0061178 | regulation of insulin secretion involved in cellul | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0048666 | neuron development | IEP | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0032956 | regulation of actin cytoskeleton organization | IEA | biological_process |