| UniProt/SwissProt ID: | EFNA4_HUMAN |
| Description: | ephrin-A4 [Source:HGNC Symbol;Acc:3224] |
| Location: | chr1 q22 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S160 | ERKSEsAHPVG | PhosphoSitePlus | |
| S166 | AHPVGsPGESG | PhosphoSitePlus | |
| S158 | CKERKsESAHP | PhosphoSitePlus | |
| Dephosphorylation site |
| EFNA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357394 | L187S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| EFNA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EFNA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EFNA4_HUMAN | EPHA5_HUMAN | ligand -> receptor | HPMR |
| EFNA4_HUMAN | EPHA6_HUMAN | ligand -> receptor | HPMR |
| EFNA4_HUMAN | EPHA2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0046875 | ephrin receptor binding | IPI | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005005 | transmembrane-ephrin receptor activity | TAS | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0031225 | anchored to membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |