Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHB4_HUMAN
Description:EPH receptor B4 [Source:HGNC Symbol;Acc:3395]
Location:chr7 q22.1
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T976QAKPGtPGGTGPhosphoSitePlus; HPRD; phosphoELM
Y590HGTKVyIDPFTPhosphoSitePlus; HPRD
Y357REDLTyALRCRfn3PhosphoSitePlus
S757LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
T953LRIGVtLAGHQSAM_1PhosphoSitePlus
T773NSSDPtYTSSLPkinase_TyrPhosphoSitePlus
Y581DKHGQyLIGHGPhosphoSitePlus
Y774SSDPTyTSSLGPkinase_TyrPhosphoSitePlus
T953LRIGVtLAGHQHPRD
S762SDFGLsRFLEEPkinase_TyrPhosphoSitePlus
T775SDPTYtSSLGGPkinase_TyrPhosphoSitePlus
T587LIGHGtKVYIDPhosphoSitePlus
T595YIDPFtYEDPNPhosphoSitePlus; HPRD
Y574GREAEySDKHGPhosphoSitePlus; HPRD
S777PTYTSsLGGKIPkinase_TyrPhosphoSitePlus
S776DPTYTsSLGGKPkinase_TyrPhosphoSitePlus
S769FLEENsSDPTYPkinase_TyrPhosphoSitePlus
S911YSAFGsVGEWLSAM_1PhosphoSitePlus
Y614EIDVSyVKIEEPhosphoSitePlus
S575REAEYsDKHGQPhosphoSitePlus
Y774SSDPTyTSSLGHPRD
T322GAPCTtPPSAPPhosphoSitePlus
S770LEENSsDPTYTPkinase_TyrPhosphoSitePlus
Y987GPAPQy_____PhosphoSitePlus
Y596IDPFTyEDPNEPhosphoSitePlus; HPRD
T321RGAPCtTPPSAPhosphoSitePlus
T544ALIAGtAVVGVRhabdo_glycop; TMPhosphoSitePlus
S769FLEENsSDPTYHPRD
S911YSAFGsVGEWLHPRD
T713NDGQFtVIQLVPkinase_TyrPhosphoSitePlus
S872FPQVVsALDKMPkinase_TyrPhosphoSitePlus
Y906QRQPHySAFGSPhosphoSitePlus; HPRD
S337SRLNGsSLHLEfn3PhosphoSitePlus
S750NILVNsNLVCKPkinase_TyrPhosphoSitePlus
S332PRSVVsRLNGSfn3PhosphoSitePlus
Y924IKMGRyEESFASAM_1PhosphoSitePlus

Dephosphorylation site
EPHB4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350896R889WGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000350896G274SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000350896D121YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000350896P346LGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000350896Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineUp2.316335961

Hyperphosphorylation site
EPHB4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB2_HUMANEPHB4_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB4_HUMANligand -> receptorHPMR
EPHB4_HUMANSDC3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0007155cell adhesionIDAbiological_process
GO:0003007heart morphogenesisISSbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001525angiogenesisISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0002042cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0005003ephrin receptor activityIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process


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