Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EFNB2_HUMAN
Description:ephrin-B2 [Source:HGNC Symbol;Acc:3227]
Location:chr13 q33.3
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y311KVSGDyGHPVYphosphoELM; RegPhos
Y330SPANIyYHPRD; phosphoELM; SysPTM
Y304VFCPHyEKVSGHPRD; RegPhos; SysPTM
S308HYEKVsGDYGHShisaPhosphoSitePlus
S325EMPPQsPANIYHPRD; phosphoELM; SysPTM
T274LSTLAtPKRSGShisa; UPF0560PhosphoSitePlus
Y304VFCPHyEKVSGShisaPhosphoSitePlus; SysPTM
Y330SPANIyYKV__PhosphoSitePlus; SysPTM
Y316YGHPVyIVQEMphosphoELM; RegPhos
Y331PANIYyKV___PhosphoSitePlus
T69KVDSKtVGQYEEphrinPhosphoSitePlus
Y316YGHPVyIVQEMShisaPhosphoSitePlus
S325EMPPQsPANIYShisaPhosphoSitePlus; SysPTM
Y330SPANIyYKVRegPhos; SysPTM
S260RHRKHsPQHTTShisa; Rifin_STEVOR; UPF0PhosphoSitePlus
S268HTTTLsLSTLAShisa; Rifin_STEVOR; UPF0PhosphoSitePlus
Y304VFCPHyEKVSGEphB2phosphoELM; RegPhos; SysPTM
Y11DSVWKyCWGVLPhosphoSitePlus
Y311KVSGDyGHPVYShisaPhosphoSitePlus

Dephosphorylation site
EFNB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000245323Q319*COSMICSkin Cancer21984974
ENSP00000245323P261LCOSMICOvarian Cancer21720365

Differential expressed protein
EFNB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EFNB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB2_HUMANEPHB4_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHB3_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHB2_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHB1_HUMANligand -> receptorHPMR
ZAGL2_HUMANEFNB2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0007155cell adhesionIDAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:2000727positive regulation of cardiac muscle cell differeISSbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0002042cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0050920regulation of chemotaxisIDAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007399nervous system developmentIEAbiological_process
GO:2000727positive regulation of cardiac muscle cell differeIEAbiological_process
GO:0001945lymph vessel developmentIEAbiological_process


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