Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EF2_HUMAN
Description:eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:3214]
Location:chr19 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S500RVMKFsVSPVVPhosphoSitePlus
T435MGPNYtPGKKEGTP_EFTU_D2PhosphoSitePlus; SysPTM
Y373RCELLyEGPPDPhosphoSitePlus; HPRD
S623DKGEVsARQELHPRD
T779SQVAGtPMFVVEFG_CPhosphoSitePlus
S623DKGEVsARQELEFG_IVPhosphoSitePlus
T724GQIIPtARRCLEFG_IVPhosphoSitePlus
T404SKMVPtSDKGRPhosphoSitePlus
T57GETRFtDTRKDHPRD; phosphoELM; RegPhos; SysPTM
T724GQIIPtARRCLHPRD
S72CITIKsTAISLGTP_EFTUPhosphoSitePlus
T54ARAGEtRFTDTEEF2KHPRD; SysPTM
Y79AISLFyELSENGTP_EFTUPhosphoSitePlus
S502MKFSVsPVVRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T59TRFTDtRKDEQHPRD; phosphoELM; RegPhos; SysPTM
Y434IMGPNyTPGKKGTP_EFTU_D2PhosphoSitePlus
T54ARAGEtRFTDTGTP_EFTUPhosphoSitePlus; SysPTM
T59TRFTDtRKDEQEEF2KHPRD; SysPTM
S76KSTAIsLFYELGTP_EFTUPhosphoSitePlus
T57GETRFtDTRKDeEF2KRegPhos; SysPTM
Y760VVGGIyGVLNREFG_CPhosphoSitePlus
T59TRFTDtRKDEQeEF2KRegPhos; SysPTM
Y579DPVVSyRETVSPhosphoSitePlus
Y265LWGDRyFDPANRegPhos
Y443KKEDLyLKPIQHPRD
S197YGEGEsGPMGNGTP_EFTUPhosphoSitePlus
S399LMMYIsKMVPTPhosphoSitePlus; HPRD
T54ARAGEtRFTDTeEF2KRegPhos; SysPTM
T73ITIKStAISLFGTP_EFTUPhosphoSitePlus
T54ARAGEtRFTDTphosphoELM; RegPhos; SysPTM
Y411DKGRFyAFGRVGTP_EFTU_D2PhosphoSitePlus
Y175EPEELyQTFQRGTP_EFTUPhosphoSitePlus
S48AGIIAsARAGEHPRD
T435MGPNYtPGKKEHPRD; SysPTM
Y443KKEDLyLKPIQGTP_EFTU_D2PhosphoSitePlus
Y730ARRCLyASVLTEFG_IVPhosphoSitePlus
T59TRFTDtRKDEQGTP_EFTUPhosphoSitePlus; SysPTM
T57GETRFtDTRKDEEF2KHPRD; SysPTM
T57GETRFtDTRKDGTP_EFTUPhosphoSitePlus; SysPTM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T59GETRFTDtRKDEQERPPP2CAHPRD
T57RAGETRFtDTRKDEQPPP2CAHPRD
T57RAGETRFtDTRKDEQPPM1AHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000307940A508VCOSMICSkin Cancer21984974
ENSP00000307940R633HCOSMICHead and Neck Cancer21798893
ENSP00000307940V137LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000307940Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.517152098
ENSP00000307940Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.917152098
ENSP00000307940Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp2.417152098
ENSP00000307940Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp2.717152098
ENSP00000307940Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000307940LeukemiaNormal vs. Cancercell lineDown0.3417022645
ENSP00000307940LeukemiaNormal vs. Cancercell lineDown0.3417022645
ENSP00000307940Oral Premalignant LesionsNormal vs. CancertissueUp1.319072117
ENSP00000307940Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000307940Oral Premalignant LesionsNormal vs. CancertissueUp1.419072117
ENSP00000307940Oral Premalignant LesionsNormal vs. CancertissueUp1.319072117
ENSP00000307940Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.218491314
ENSP00000307940hepatitis B virusNormal vs. CancertissueUp2.914654528
ENSP00000307940hepatitis C virusNormal vs. CancertissueUp2.914654528
ENSP00000307940Hepatocellular CarcinomaNormal vs. CancertissueUp2.914654528
ENSP00000307940Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000307940Lung CancerCancer vs. Cancercell lineDown17284061
ENSP00000307940Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown0.4218253933
ENSP00000307940Breast CancerNormal vs. CancertissueUp6.220005186
ENSP00000307940Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000307940Breast CancerNormal vs. Cancercell lineUp1.120052998
ENSP00000307940Breast CancerMetastasiscell lineDown0.6820052998
ENSP00000307940Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000307940Renal CancerNormal vs. CancertissueUp0.8-11.412923786
ENSP00000307940Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.719714814
ENSP00000307940Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp2.119714814
ENSP00000307940Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496
ENSP00000307940Gastric CancerNormal vs. CancertissueDown0.4515761955
ENSP00000307940Gastric CancerNormal vs. CancertissueDown0.515761955
ENSP00000307940Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineUp1.620944110
ENSP00000307940Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineUp3.120944110

Hyperphosphorylation site
EF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANEF2_HUMANkinase -> substrateRegPhos
EF2K_HUMANEF2_HUMANkinase -> substrateHPRD
PP2AA_HUMANEF2_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANEF2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
EF2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006412translationTASbiological_process
GO:0006414translational elongationTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0006414translational elongationIEAbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0003746translation elongation factor activityIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005844polysomeIEAcellular_component


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