| UniProt/SwissProt ID: | DYR1A_HUMAN |
| Description: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A [Source:HGNC Symbol;Acc:3091] |
| Location: | chr21 q22.13 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y319 | LGQRIyQYIQS | Pkinase | PhosphoSitePlus |
| Y321 | QRIYQyIQSRF | Pkinase | PhosphoSitePlus; SysPTM |
| Y147 | DDNYDyIVKNG | PhosphoSitePlus; HPRD | |
| Y145 | YDDDNyDYIVK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T751 | EESPMtGVCVQ | HPRD | |
| S324 | YQYIQsRFYRS | Pkinase | PhosphoSitePlus |
| Y310 | LGQRIyQYIQS | HPRD | |
| Y136 | YDDDNyDYIVK | HPRD | |
| Y319 | LGQRIyQYIQS | autocatalysis | RegPhos |
| S758 | VCVQQsPVASS | PhosphoSitePlus | |
| S529 | SGRARsDPTHQ | PhosphoSitePlus; HPRD | |
| Y319 | LGQRIyQYIQS | HPRD; phosphoELM; RegPhos | |
| S706 | NLTVYsNPRQE | PhosphoSitePlus | |
| S519 | SSGGSsGTSNS | DYRK1A | HPRD; RegPhos |
| Y138 | DDNYDyIVKNG | HPRD | |
| Y321 | QRIYQyIQSRF | autocatalysis | RegPhos; SysPTM |
| Y159 | KWMDRyEIDSL | Pkinase | PhosphoSitePlus |
| S555 | DCETHsPQVRQ | PhosphoSitePlus | |
| Y321 | QRIYQyIQSRF | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y312 | QRIYQyIQSRF | HPRD | |
| Y136 | KERKVyNDGYD | PhosphoSitePlus; HPRD | |
| S520 | SGRARsDPTHQ | DYRK1A | HPRD |
| Y705 | VNLTVySNPRQ | PhosphoSitePlus | |
| S749 | VCVQQsPVA | HPRD | |
| S529 | SGRARsDPTHQ | DYRK1A | RegPhos |
| Y112 | INEVYyAKKKR | PhosphoSitePlus | |
| S748 | ADREEsPMTGV | PhosphoSitePlus; HPRD | |
| Y131 | VYNDGyDDDNY | HPRD | |
| Y140 | VYNDGyDDDNY | HPRD | |
| S758 | VCVQQsPVA | HPRD | |
| Y111 | HINEVyYAKKK | PhosphoSitePlus | |
| Y219 | DTEMKyYIVHL | autocatalysis | RegPhos |
| S538 | HQHRHsGGHFT | PhosphoSitePlus | |
| Y127 | KERKVyNDGYD | HPRD | |
| S739 | ADREEsPMTGV | HPRD | |
| T742 | EESPMtGVCVQ | HPRD | |
| Dephosphorylation site |
| DYR1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000381932 | I283V | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| DYR1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DYR1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYR1A_HUMAN | DYN1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | DYR1A_HUMAN | kinase -> substrate | RegPhos |
| DYR1A_HUMAN | DYR1A_HUMAN | kinase -> substrate | RegPhos |
| DYR1A_HUMAN | SF3B1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| DYR1A_HUMAN | FOXO1_HUMAN | kinase -> substrate | RegPhos |
| DYR1A_HUMAN | CCNL2_HUMAN | kinase -> substrate | RegPhos |
| DYR1A_HUMAN | CREB1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| DYR1A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0048156 | tau protein binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | ISS | biological_process |
| GO:0043621 | protein self-association | IEA | molecular_function |
| GO:0043518 | negative regulation of DNA damage response, signal | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0090312 | positive regulation of protein deacetylation | IEA | biological_process |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IDA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016607 | nuclear speck | IEA | cellular_component |