| UniProt/SwissProt ID: | DX39A_HUMAN |
| Description: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A [Source:HGNC Symbol;Acc:17821] |
| Location: | chr19 p13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S183 | LVRNRsFSLKN | DEAD | PhosphoSitePlus |
| T171 | HVVVGtPGRIL | HPRD; phosphoELM | |
| S40 | KGSYVsIHSSG | PhosphoSitePlus; HPRD; phosphoELM | |
| S37 | KDIKGsYVSIH | PhosphoSitePlus; HPRD | |
| T171 | HVVVGtPGRIL | DEAD | PhosphoSitePlus |
| Y265 | GLQQYyVKLKD | PhosphoSitePlus | |
| T382 | AGRFGtKGLAI | PhosphoSitePlus | |
| Y13 | NDLLDyDEEEE | PhosphoSitePlus | |
| S43 | YVSIHsSGFRD | PhosphoSitePlus | |
| S145 | PSVKVsVFFGG | DEAD | PhosphoSitePlus |
| S25 | QAPQEsTPAPP | HPRD | |
| S426 | TYIEQsR____ | PhosphoSitePlus | |
| S426 | TYIEQ | HPRD | |
| Y38 | DIKGSyVSIHS | PhosphoSitePlus | |
| Dephosphorylation site |
| DX39A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000242776 | R134H | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000242776 | R174H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| DX39A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DX39A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK4_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL5_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DX39A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | IGI | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IGI | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |