| UniProt/SwissProt ID: | DVL3_HUMAN |
| Description: | dishevelled, dsh homolog 3 (Drosophila) [Source:HGNC Symbol;Acc:3087] |
| Location: | chr3 q27.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S612 | HTTRSsLRGPR | Dsh_C | PhosphoSitePlus |
| S700 | TASRQsFRMAM | Dsh_C | PhosphoSitePlus |
| S204 | SRFSSsTEQSS | Dishevelled | PhosphoSitePlus |
| T608 | SESDHtTRSSL | Dsh_C | PhosphoSitePlus |
| T346 | PRGCFtLPRSE | PhosphoSitePlus | |
| S596 | PKAGDsKSGGS | Dsh_C | PhosphoSitePlus |
| S41 | VLQRPsYKFFF | DIX | PhosphoSitePlus |
| S244 | TDSTMsLNIIT | PhosphoSitePlus | |
| S203 | TSRFSsSTEQS | Dishevelled | PhosphoSitePlus |
| S125 | HAGGGsQENLD | PhosphoSitePlus | |
| S192 | TSFFDsDEDDS | Dishevelled | PhosphoSitePlus |
| Y257 | LNMEKyNFLGI | PDZ | PhosphoSitePlus |
| S208 | SSTEQsSASRL | Dishevelled | PhosphoSitePlus |
| S202 | STSRFsSSTEQ | Dishevelled | PhosphoSitePlus |
| T609 | ESDHTtRSSLR | Dsh_C | PhosphoSitePlus |
| S603 | SGGSGsESDHT | Dsh_C | PhosphoSitePlus |
| S192 | TSFFDsDEDDS | HPRD; phosphoELM | |
| S48 | KFFFKsMDDDF | DIX | PhosphoSitePlus |
| S268 | SIVGQsNERGD | PDZ | PhosphoSitePlus |
| S209 | STEQSsASRLM | Dishevelled | PhosphoSitePlus |
| Dephosphorylation site |
| DVL3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316054 | R168Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316054 | R168Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316054 | D94V | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000316054 | R216T | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| DVL3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DVL3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MARK2_HUMAN | DVL3_HUMAN | kinase -> substrate | NetPath |
| KC1D_HUMAN | DVL3_HUMAN | kinase -> substrate | NetPath |
| KC1E_HUMAN | DVL3_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04330 | Notch signaling pathway |
| hsa05200 | Pathways in cancer |
| hsa04916 | Melanogenesis |
| hsa04310 | Wnt signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa05217 | Basal cell carcinoma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005109 | frizzled binding | IPI | molecular_function |
| GO:0003148 | outflow tract septum morphogenesis | IEA | biological_process |
| GO:0002020 | protease binding | IPI | molecular_function |
| GO:0005938 | cell cortex | IBA | cellular_component |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0035567 | non-canonical Wnt receptor signaling pathway | IMP | biological_process |
| GO:0090103 | cochlea morphogenesis | IEA | biological_process |
| GO:0038031 | non-canonical Wnt receptor signaling pathway via J | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003007 | heart morphogenesis | IEA | biological_process |
| GO:0060070 | canonical Wnt receptor signaling pathway | IDA | biological_process |
| GO:0090179 | planar cell polarity pathway involved in neural tu | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0046982 | protein heterodimerization activity | IDA | molecular_function |
| GO:0060071 | Wnt receptor signaling pathway, planar cell polari | IDA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0016055 | Wnt receptor signaling pathway | IDA | biological_process |
| GO:0060026 | convergent extension | IBA | biological_process |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0043507 | positive regulation of JUN kinase activity | IMP | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0008013 | beta-catenin binding | IDA | molecular_function |