Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DUS3_HUMAN
Description:dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:3069]
Location:chr17 q21.31
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S149KMDVKsALSIVDSPcPhosphoSitePlus
Y23DGSGCySLPSQPhosphoSitePlus
T133YSRSPtLVIAYHPRD
Y138TLVIAyLMMRQSykRegPhos
S8GSFELsVQDLNPhosphoSitePlus; HPRD
Y101FNLSAyFERAADSPcPhosphoSitePlus
Y138TLVIAyLMMRQZAP70HPRD; phosphoELM; RegPhos
Y38VTPRIyVGNASDSPcPhosphoSitePlus
Y138TLVIAyLMMRQSYKphosphoELM
Y138TLVIAyLMMRQDSPcPhosphoSitePlus
Y38VTPRIyVGNASHPRD

Dephosphorylation site
DUS3_HUMAN do not have dephosphorylation site.

Mutation site
DUS3_HUMAN do not have mutation site.

Differential expressed protein
DUS3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DUS3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMANDUS3_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
ZAP70_HUMANDUS3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
DUS3_HUMANMP2K2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0033549MAP kinase phosphatase activityIMPmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0050860negative regulation of T cell receptor signaling pIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolIDAcellular_component
GO:0050868negative regulation of T cell activationIDAbiological_process
GO:0004725protein tyrosine phosphatase activityIDAmolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0000188inactivation of MAPK activityIMPbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0008138protein tyrosine/serine/threonine phosphatase actiIDAmolecular_function
GO:0070373negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0001772immunological synapseIDAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0046329negative regulation of JNK cascadeIDAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0008138protein tyrosine/serine/threonine phosphatase actiIEAmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0043409negative regulation of MAPK cascadeIMPbiological_process


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