Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DTX1_HUMAN
Description:deltex homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:3060]
Location:chr12 q24.13
Node attribute:substrate; ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S215STRAAsNAILAPhosphoSitePlus
S221NAILAsQRRKAPhosphoSitePlus
S279GAPPRsPGAPGPhosphoSitePlus

Dephosphorylation site
DTX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000257600A598TTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000257600M447ICOSMICHead and Neck Cancer21798893
ENSP00000257600V575ACOSMICLung Cancer20668451

Differential expressed protein
DTX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DTX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK4_HUMANDTX1_HUMANkinase -> substrateRobert H Newman (2013)
DTX1_HUMANM3K1_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0007219Notch signaling pathwayTASbiological_process
GO:0006351transcription, DNA-dependentNASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0045581negative regulation of T cell differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0008593regulation of Notch signaling pathwayIGIbiological_process
GO:0016567protein ubiquitinationIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0005112Notch bindingIDAmolecular_function
GO:0045665negative regulation of neuron differentiationIGIbiological_process
GO:0005829cytosolTAScellular_component
GO:0010001glial cell differentiationIEAbiological_process
GO:0016874ligase activityIEAmolecular_function


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