Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DPYL2_HUMAN
Description:dihydropyrimidinase-like 2 [Source:HGNC Symbol;Acc:3014]
Location:chr8 p21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y499VPRGLyDGPVCPhosphoSitePlus; RegPhos
T555IPRRTtQRIVAROCK_groupphosphoELM; RegPhos
S308TSPPLsPDPTTAmidohydro_1PhosphoSitePlus
Y431NSSLEyNIFEGPhosphoSitePlus; RegPhos
S570RANITsLG___PhosphoSitePlus
T514TPKTVtPASSAGSK-3_betaphosphoELM
T509CEVSVtPKTVTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y32DDQSFyADIYMPhosphoSitePlus; RegPhos
T514TPKTVtPASSAPhosphoSitePlus; phosphoELM; RegPhos
T555IPRRTtQRIVAPhosphoSitePlus
T554NIPRRtTQRIVPhosphoSitePlus
T74GIDVHtRFQMPAmidohydro_1PhosphoSitePlus
T514TPKTVtPASSAGSK3BHPRD
S542SGFSLsGAQIDHPRD
T555IPRRTtQRIVAROCK1HPRD; RegPhos
T555IPRRTtQRIVAROCK2phosphoELM; RegPhos
T514TPKTVtPASSAGSK3B(GSK3 betaRegPhos
Y479FPDFVyKRIKAPhosphoSitePlus
S304AAFVTsPPLSPAmidohydro_1PhosphoSitePlus
S30VNDDQsFYADIPhosphoSitePlus
S518VTPASsAKTSPGSK3B(GSK3 betaRegPhos
T509CEVSVtPKTVTGSK3B(GSK3 betaRegPhos; SysPTM
T512SVTPKtVTPASPhosphoSitePlus; HPRD
S518VTPASsAKTSPGSK-3_betaphosphoELM
T358EGTNGtEERMSAmidohydro_1PhosphoSitePlus
S517TVTPAsSAKTSPhosphoSitePlus; HPRD; phosphoELM
S465HVTEGsGRYIPRegPhos
Y3___MSyQGKKNPhosphoSitePlus
S507PVCEVsVTPKTPhosphoSitePlus
T57PGGVKtIEAHSPhosphoSitePlus
T509CEVSVtPKTVTGSK-3_betaphosphoELM; SysPTM
T521ASSAKtSPAKQPhosphoSitePlus; HPRD
T462GTLHVtEGSGRRegPhos
S518VTPASsAKTSPPhosphoSitePlus; HPRD; RegPhos
S537RNLHQsGFSLSPhosphoSitePlus; HPRD
S522SSAKTsPAKQQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S540HQSGFsLSGAQPhosphoSitePlus
S2____MsYQGKKPhosphoSitePlus

Dephosphorylation site
DPYL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309539R481CHPIColorectal Cancer16959974
ENSP00000309539I148VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000309539D367NCOSMICSkin Cancer21984974
ENSP00000428909R481CBIOMARTColorectal Cancer21930507, 21930502
ENSP00000309539R481CSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000309539colorectal cancerNormal vs. CancertissueUp1.619098285
ENSP00000309539Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.3116319398
ENSP00000309539Esophageal CancerNormal vs. CancertissueDown0.3319142970
ENSP00000309539Esophageal CancerNormal vs. CancertissueDown0.3419142970
ENSP00000309539Breast CancerNormal vs. CancertissueUp2.320005186
ENSP00000309539Breast CancerNormal vs. CancertissueDown0.4920739354
ENSP00000309539Renal CancerNormal vs. CancertissueUp19164279
ENSP00000309539Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.6316807943
ENSP00000309539Pancreatic CancerNormal vs. CancertissueDown0.515526344

Hyperphosphorylation site
DPYL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANDPYL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ROCK1_HUMANDPYL2_HUMANkinase -> substrateHPRD; RegPhos
ROCK2_HUMANDPYL2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANDPYL2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0021510spinal cord developmentIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0004157dihydropyrimidinase activityTASmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0016787hydrolase activityIEAmolecular_function
GO:0016810hydrolase activity, acting on carbon-nitrogen (butIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0007010cytoskeleton organizationISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0014049positive regulation of glutamate secretionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007420brain developmentIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0021772olfactory bulb developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0048489synaptic vesicle transportIEAbiological_process
GO:0030426growth coneIEAcellular_component
GO:0007399nervous system developmentTASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0045664regulation of neuron differentiationIEAbiological_process
GO:0016812hydrolase activity, acting on carbon-nitrogen (butIEAmolecular_function
GO:0006208pyrimidine nucleobase catabolic processIEAbiological_process
GO:0006139nucleobase-containing compound metabolic processTASbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0005515protein bindingIEAmolecular_function