| UniProt/SwissProt ID: | DPOLB_HUMAN |
| Description: | polymerase (DNA directed), beta [Source:HGNC Symbol;Acc:9174] |
| Location: | chr8 p11.21 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y39 | HKYNAyRKAAS | PhosphoSitePlus | |
| S44 | YRKAAsVIAKY | HPRD | |
| T67 | LPGVGtKIAEK | PhosphoSitePlus | |
| Y49 | SVIAKyPHKIK | PhosphoSitePlus | |
| S180 | ATVCGsFRRGA | PhosphoSitePlus | |
| S55 | PHKIKsGAEAK | HPRD | |
| Y36 | QAIHKyNAYRK | PhosphoSitePlus | |
| Y250 | NDEKEyPHRRI | PhosphoSitePlus | |
| Dephosphorylation site |
| DPOLB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265421 | G80R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265421 | N37H | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000265421 | N281S | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| DPOLB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DPOLB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | DPOLB_HUMAN | TF -> target gene | TRANSFAC |
| ATF2_HUMAN | DPOLB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| DPOLB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005876 | spindle microtubule | IDA | cellular_component |
| GO:0016829 | lyase activity | IDA | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IMP | biological_process |
| GO:0008017 | microtubule binding | IDA | molecular_function |
| GO:0006284 | base-excision repair | IDA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0045471 | response to ethanol | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0005874 | microtubule | IDA | cellular_component |
| GO:0016779 | nucleotidyltransferase activity | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0006290 | pyrimidine dimer repair | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |