Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DMPK_HUMAN
Description:dystrophia myotonica-protein kinase [Source:HGNC Symbol;Acc:2933]
Location:chr19 q13.32
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T536GATAVtGVPSPIncA; AP_endonuc_2; TmembPhosphoSitePlus
S2____MsAEVRLPhosphoSitePlus
T533QAEGAtAVTGVIncA; AP_endonuc_2; TmembPhosphoSitePlus

Dephosphorylation site
DMPK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000291270T544MDing2008Lung Cancer18948947
ENSP00000345997S51YBIOMARTBreast Cancer21930507, 21930502
ENSP00000291270L438VGreenman2007Lung Cancer17344846, 18428421

Differential expressed protein
DMPK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DMPK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DMPK_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
DMPK_HUMANTGFI1_HUMANkinase -> substrateRobert H Newman (2013)
DMPK_HUMANMYPT1_HUMANkinase -> substrateHPRD
DMPK_HUMANSRF_HUMANkinase -> substrateRegPhos
DMPK_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DMPK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031307integral to mitochondrial outer membraneIDAcellular_component
GO:0010830regulation of myotube differentiationISSbiological_process
GO:0051823regulation of synapse structural plasticityIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0010657muscle cell apoptotic processIDAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0031965nuclear membraneISScellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0031965nuclear membraneIEAcellular_component
GO:0031307integral to mitochondrial outer membraneIEAcellular_component
GO:0008016regulation of heart contractionIEAbiological_process
GO:0014853regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006998nuclear envelope organizationIMPbiological_process
GO:0010830regulation of myotube differentiationIEAbiological_process
GO:0008016regulation of heart contractionIDAbiological_process
GO:0033017sarcoplasmic reticulum membraneIEAcellular_component
GO:0005886plasma membraneISScellular_component
GO:0005789endoplasmic reticulum membraneISScellular_component
GO:0033017sarcoplasmic reticulum membraneISScellular_component
GO:0005829cytosolISScellular_component
GO:0014722regulation of skeletal muscle contraction by calciIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0005640nuclear outer membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006874cellular calcium ion homeostasisISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0017020myosin phosphatase regulator activityIDAmolecular_function
GO:0006998nuclear envelope organizationIEAbiological_process


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