Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DCLK2_HUMAN
Description:doublecortin-like kinase 2 [Source:HGNC Symbol;Acc:19002]
Location:chr4 q31.23
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y505ANALRyLHGLSPkinase_CAMKPhosphoSitePlus
S182LAAASsVKSEVPhosphoSitePlus; HPRD
Y83RNGDRyFKGLVPhosphoSitePlus
S93VFAISsDRFRSDCXPhosphoSitePlus
S185ASSVKsEVKESPhosphoSitePlus
T173NIKGGtSRALAPhosphoSitePlus
S347PTSPGsFRGLKPhosphoSitePlus
T61FYRTRtLQALSPhosphoSitePlus
T685QNSTTtGVSVIPhosphoSitePlus
S340TKSSSsSPTSPPhosphoSitePlus
S308YSGSKsPGPSRPhosphoSitePlus
T331SSQLStPKSTKPhosphoSitePlus
S344SSSPTsPGSFRPhosphoSitePlus
S312KSPGPsRRSKSPhosphoSitePlus
S6MASTRsIELEHPhosphoSitePlus

Dephosphorylation site
DCLK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296550C524WTCGAOvarian Cancer21720365, 18772890
ENSP00000303887D496NCOSMICGastric Cancer21097718
ENSP00000296550H435RTCGAOvarian Cancer21720365, 18772890
ENSP00000296550E594KTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
DCLK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DCLK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DCLK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
DCLK2_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DCLK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function


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