Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:COF2_HUMAN
Description:cofilin 2 (muscle) [Source:HGNC Symbol;Acc:1875]
Location:chr14 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T88ALYDAtYETKECofilin_ADFPhosphoSitePlus
S3MASGVtVNRegPhos; SysPTM
Y85CRYALyDATYEHPRD
S3___MAsGVTVNPhosphoSitePlus; SysPTM
S23MKVRKsSTQEECofilin_ADFPhosphoSitePlus
S3VTVNLIMK1HPRD; phosphoELM; SysPTM
Y85CRYALyDATYECofilin_ADFPhosphoSitePlus
S94YETKEsKKEDLCofilin_ADFPhosphoSitePlus
Y89LYDATyETKESCofilin_ADFPhosphoSitePlus
S24KVRKSsTQEEICaMK2_groupRegPhos
S24KVRKSsTQEEICaM-KII_groupphosphoELM
Y89LYDATyETKESHPRD; RegPhos
Y117KSKMIyASSKDCofilin_ADFPhosphoSitePlus
T91DATYEtKESKKCofilin_ADFPhosphoSitePlus
S3VTVNphosphoELM; SysPTM
Y68TVEDPyTSFVKCofilin_ADFPhosphoSitePlus
S24KVRKSsTQEEIRegPhos
S3MASGVtVNLIMK1RegPhos; SysPTM
Y82LNDCRyALYDACofilin_ADFPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S3sGVTVNDESSH1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340635I47MSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000298159I47MSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 18428421, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000298159Hepatocellular CarcinomaNormal vs. CancertissueUp3.115759316
ENSP00000298159Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7718973835
ENSP00000298159Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.6718973835
ENSP00000298159Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7719714814
ENSP00000298159Uterine CancerCancer vs. Cancercell lineDown17616526

Hyperphosphorylation site
COF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNI3K_HUMANCOF2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCOF2_HUMANkinase -> substrateRegPhos
LIMK1_HUMANCOF2_HUMANkinase -> substrateHPRD; RegPhos
KCC4_HUMANCOF2_HUMANkinase -> substrateRobert H Newman (2013)
SSH1_HUMANCOF2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05133Pertussis
hsa04360Axon guidance
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0016363nuclear matrixIEAcellular_component


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