Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SSH1_HUMAN
Description:slingshot homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:30579]
Location:chr12 q24.11
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T430QKRSItRPNAGDSPcPhosphoSitePlus
S441FMRQLsEYEGIDSPcPhosphoSitePlus
Y443RQLSEyEGILDDSPcPhosphoSitePlus
S935SNLTRsSSSDSPhosphoSitePlus
S938TRSSSsDSIHSPhosphoSitePlus
S576KLEFGsPKGRSPhosphoSitePlus; HPRD
S464RQQTDsSLQQPPhosphoSitePlus
S428VKQKRsITRPNDSPcPhosphoSitePlus
T403SRSAStVIAYADSPcPhosphoSitePlus
S978LKRSHsLAKLGPhosphoSitePlus; phosphoELM
S834LERLKsVPADPPhosphoSitePlus
T5QRSPHPRD
S937LTRSSsSDSIHPhosphoSitePlus; HPRD; phosphoELM
S465QQTDSsLQQPVPhosphoSitePlus
Y646KVKPSyKSCADPhosphoSitePlus
Y407STVIAyAMKEFDSPcPhosphoSitePlus
S515CFRRLsDPLLPPhosphoSitePlus; HPRD
T462LWRQQtDSSLQPhosphoSitePlus
S1042PENLKsPSWMSPhosphoSitePlus; phosphoELM
T5_MALVtLQRSPPhosphoSitePlus
S936NLTRSsSSDSIPhosphoSitePlus
S894SLEGGsLKSPPPhosphoSitePlus
S37RKLNLsLSESFPhosphoSitePlus; HPRD
T933MSSNLtRSSSSPhosphoSitePlus
S897GGSLKsPPPFFPhosphoSitePlus
S645NKVKPsYKSCAPhosphoSitePlus
T1021HEPQGtPRDPAPhosphoSitePlus
S971GLTVSsPLKRSPhosphoSitePlus; HPRD; phosphoELM
S976SPLKRsHSLAKHPRD
S402VSRSAsTVIAYDSPcPhosphoSitePlus
T590LQVEEtEREEGPhosphoSitePlus
S854SRLEAsIPEESPhosphoSitePlus
S57LQQGSsPQGQRPhosphoSitePlus; HPRD

Dephosphorylation site
SSH1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000315713R144QCOSMICOvarian Cancer21720365
ENSP00000315713R277HCOSMICOvarian Cancer21720365
ENSP00000315713E25GCOSMICOvarian Cancer21720365
ENSP00000315713E298KCOSMICHead and Neck Cancer21798893
ENSP00000315713M873ICOSMICSkin Cancer21984974
ENSP00000315713A401VCOSMICOvarian Cancer21720365

Differential expressed protein
SSH1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SSH1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SSH1_HUMANCOF1_HUMANphosphatase -> substrateHPRD; KEGG
SSH1_HUMANCOF2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016311dephosphorylationIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0071318cellular response to ATPIDAbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0000902cell morphogenesisIMPbiological_process
GO:0050770regulation of axonogenesisIBAbiological_process
GO:0032154cleavage furrowIEAcellular_component
GO:0016791phosphatase activityIEAmolecular_function
GO:0003779actin bindingIDAmolecular_function
GO:0008064regulation of actin polymerization or depolymerizaIBAbiological_process
GO:0004721phosphoprotein phosphatase activityIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0030496midbodyIEAcellular_component
GO:0030036actin cytoskeleton organizationIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006470protein dephosphorylationIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0032268regulation of cellular protein metabolic processIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0010591regulation of lamellipodium assemblyIBAbiological_process
GO:0008138protein tyrosine/serine/threonine phosphatase actiIBAmolecular_function


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