| UniProt/SwissProt ID: | CNOT6_HUMAN |
| Description: | CCR4-NOT transcription complex, subunit 6 [Source:HGNC Symbol;Acc:14099] |
| Location: | chr5 q35.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T447 | YNESLtNFSCH | Exo_endo_phos | PhosphoSitePlus |
| S445 | LRYNEsLTNFS | Exo_endo_phos | PhosphoSitePlus |
| S212 | YGYCPsWALNW | Exo_endo_phos | PhosphoSitePlus |
| S42 | SGKVRsLSASL | PhosphoSitePlus | |
| T54 | SLTHLtALHLS | LRR_4 | PhosphoSitePlus |
| Y201 | VLCDKyATRQL | Exo_endo_phos | PhosphoSitePlus |
| S49 | SASLWsLTHLT | PhosphoSitePlus | |
| Dephosphorylation site |
| CNOT6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377024 | P406L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CNOT6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CNOT6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK6_HUMAN | CNOT6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK4_HUMAN | CNOT6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | CNOT6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | CNOT6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CNOT6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004535 | poly(A)-specific ribonuclease activity | TAS | molecular_function |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:2000327 | positive regulation of ligand-dependent nuclear re | IDA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deaden | TAS | biological_process |