| UniProt/SwissProt ID: | CLTR1_HUMAN |
| Description: | cysteinyl leukotriene receptor 1 [Source:HGNC Symbol;Acc:17451] |
| Location: | chrX q21.1 |
| Node attribute: | PPI(source); GPCR; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S315 | RKHSLsSVTYV | PhosphoSitePlus | |
| S313 | TFRKHsLSSVT | PhosphoSitePlus | |
| Y319 | LSSVTyVPRKK | PhosphoSitePlus | |
| S307 | FRKRLsTFRKH | PhosphoSitePlus | |
| T308 | RKRLStFRKHS | PhosphoSitePlus | |
| S316 | KHSLSsVTYVP | PhosphoSitePlus | |
| Dephosphorylation site |
| CLTR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362401 | I123T | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000362401 | P292R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CLTR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLTR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLTR1_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| CLTR1_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| CLTR1_HUMAN | GNA11_HUMAN | other | KEGG |
| GLHA_HUMAN | CLTR1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0006952 | defense response | TAS | biological_process |
| GO:0004974 | leukotriene receptor activity | IEA | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0006935 | chemotaxis | IEA | biological_process |
| GO:0045766 | positive regulation of angiogenesis | IEA | biological_process |
| GO:0045907 | positive regulation of vasoconstriction | IEA | biological_process |
| GO:0007585 | respiratory gaseous exchange | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |