| UniProt/SwissProt ID: | CAN1_HUMAN |
| Description: | calpain 1, (mu/I) large subunit [Source:HGNC Symbol;Acc:1476] |
| Location: | chr11 q13.1 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S77 | DLGPNsSKTYG | phosphoELM | |
| Y371 | WNTTLyEGTWR | Calpain_III | PhosphoSitePlus |
| T374 | TLYEGtWRRGS | Calpain_III | PhosphoSitePlus |
| T80 | PNSSKtYGIKW | phosphoELM | |
| T380 | WRRGStAGGCR | phosphoELM | |
| Y387 | GGCRNyPATFW | Calpain_III | PhosphoSitePlus |
| Y446 | IGFAVyEVPPE | phosphoELM | |
| T362 | ALKSRtIRKWN | phosphoELM | |
| Y42 | YLGQDyEQLRV | PhosphoSitePlus | |
| T354 | EICNLtPDALK | Peptidase_C2 | PhosphoSitePlus |
| S78 | LGPNSsKTYGI | phosphoELM | |
| Y410 | DDPDDyGDRES | Calpain_III | PhosphoSitePlus |
| S360 | PDALKsRTIRK | phosphoELM | |
| Y81 | NSSKTyGIKWK | phosphoELM | |
| S379 | TWRRGsTAGGC | phosphoELM | |
| Dephosphorylation site |
| CAN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CAN1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000279247 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 18 | 14726492 | ENSP00000279247 | Breast Cancer | Metastasis | tissue | Down | 18257521 |
| Hyperphosphorylation site |
| CAN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CAN1_HUMAN | CD5R1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05010 | Alzheimer's disease |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa04210 | Apoptosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0004198 | calcium-dependent cysteine-type endopeptidase acti | IEA | molecular_function |
| GO:0032801 | receptor catabolic process | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |