Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CAN1_HUMAN
Description:calpain 1, (mu/I) large subunit [Source:HGNC Symbol;Acc:1476]
Location:chr11 q13.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S77DLGPNsSKTYGphosphoELM
Y371WNTTLyEGTWRCalpain_IIIPhosphoSitePlus
T374TLYEGtWRRGSCalpain_IIIPhosphoSitePlus
T80PNSSKtYGIKWphosphoELM
T380WRRGStAGGCRphosphoELM
Y387GGCRNyPATFWCalpain_IIIPhosphoSitePlus
Y446IGFAVyEVPPEphosphoELM
T362ALKSRtIRKWNphosphoELM
Y42YLGQDyEQLRVPhosphoSitePlus
T354EICNLtPDALKPeptidase_C2PhosphoSitePlus
S78LGPNSsKTYGIphosphoELM
Y410DDPDDyGDRESCalpain_IIIPhosphoSitePlus
S360PDALKsRTIRKphosphoELM
Y81NSSKTyGIKWKphosphoELM
S379TWRRGsTAGGCphosphoELM

Dephosphorylation site
CAN1_HUMAN do not have dephosphorylation site.

Mutation site
CAN1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000279247hepatitis B virusNormal vs. CancertissueUp1814726492
ENSP00000279247Breast CancerMetastasistissueDown18257521

Hyperphosphorylation site
CAN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CAN1_HUMANCD5R1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04141Protein processing in endoplasmic reticulum
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0004198calcium-dependent cysteine-type endopeptidase actiIEAmolecular_function
GO:0032801receptor catabolic processIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component


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