Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD44_HUMAN
Description:CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:1681]
Location:chr11 p13
Node attribute:substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S629CIAVNsRRRCGHPRD
S448EDRKPsGLNGEHPRD
Y412RWHEGyRQTPKPhosphoSitePlus
T720KESSEtPDQFMBravo_FIGEYPhosphoSitePlus
S337VNKESsETPDQHPRD
S437KLVINsGNGAVHPRD
S706GEASKsQEMVHHPRD; phosphoELM; RegPhos; SysPTM
S457GEASKsQEMVHHPRD
T572TKESRtFIPVTPhosphoSitePlus
S706GEASKsQEMVHBravo_FIGEYPhosphoSitePlus; SysPTM
S468LVNKEsSETPDHPRD
S661LNGEAsKSQEMHPRD
S423CIAVNsRRRCGHPRD
S291CIAVNsRRRCGHPRD
S663GEASKsQEMVHHPRD
S672CIAVNsRRRCGPKCa(PKC alphaRegPhos
S675VNKESsETPDQHPRD
S697EDRKPsGLNGEHPRD; phosphoELM; RegPhos
S672CIAVNsRRRCGPKC_alphaphosphoELM
T544GSFGVtAVTVGHPRD
S674LVNKEsSETPDHPRD
T62NSTLPtMAQMEXlinkPhosphoSitePlus
S672CIAVNsRRRCGBravo_FIGEYPhosphoSitePlus
S686KLVINsGNGAVHPRD; phosphoELM; RegPhos
T222DRIPAtTLMSTPhosphoSitePlus
T62NSTLPtMAQMEHPRD; phosphoELM
S45GRYSIsRTEAAHPRD; phosphoELM
S643KLVINsGNGAVHPRD
S704LNGEAsKSQEMHPRD
S718VNKESsETPDQHPRD
S686KLVINsGNGAVBravo_FIGEYPhosphoSitePlus
T587GSFGVtAVTVGHPRD
T726PDQFMtADETRBravo_FIGEYPhosphoSitePlus
T163KGEYRtNPEDIPhosphoSitePlus
S171EDIYPsNPTDDPhosphoSitePlus
S305KLVINsGNGAVHPRD
S58CKAFNsTLPTMHPRD; phosphoELM
S323LNGEAsKSQEMHPRD
S672CIAVNsRRRCGHPRD; RegPhos
S672CIAVNsRRRCGPKC_groupRegPhos
T338GSFGVtAVTVGHPRD
S336LVNKEsSETPDHPRD
S325GEASKsQEMVHHPRD
S455LNGEAsKSQEMHPRD
T677KESSEtPDQFMHPRD
S704LNGEAsKSQEMBravo_FIGEYPhosphoSitePlus
S316EDRKPsGLNGEHPRD
T471KESSEtPDQFMHPRD
T339KESSEtPDQFMHPRD
S469VNKESsETPDQHPRD
S291RDRHLsFSGSGPKC_groupphosphoELM; RegPhos
S697EDRKPsGLNGEBravo_FIGEYPhosphoSitePlus
T720KESSEtPDQFMHPRD; phosphoELM; RegPhos
S718VNKESsETPDQBravo_FIGEYPhosphoSitePlus
S291RDRHLsFSGSGRegPhos
S654EDRKPsGLNGEHPRD
S717LVNKEsSETPDHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S457LNGEASKsQEMVHLVHPRD
S325LNGEASKsQEMVHLVHPRD
S663LNGEASKsQEMVHLVHPRD
S706LNGEASKsQEMVHLVHPRD

Mutation site
CD44_HUMAN do not have mutation site.

Differential expressed protein
CD44_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD44_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HAS2_HUMANCD44_HUMANligand -> receptorHPMR
OSTP_HUMANCD44_HUMANligand -> receptorHPMR
ZAGL2_HUMANCD44_HUMANkinase -> substrateRegPhos
KPCA_HUMANCD44_HUMANkinase -> substrateRobert H Newman (2013)
LAMC3_HUMANCD44_HUMANotherKEGG
FINC_HUMANCD44_HUMANotherKEGG
CO1A1_HUMANCD44_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04640Hematopoietic cell lineage
hsa05131Shigellosis
hsa04512ECM-receptor interaction
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030214hyaluronan catabolic processIDAbiological_process
GO:0005540hyaluronic acid bindingIDAmolecular_function
GO:0005887integral to plasma membraneNAScellular_component
GO:0016337cell-cell adhesionNASbiological_process
GO:0044344cellular response to fibroblast growth factor stimIDAbiological_process
GO:0004888transmembrane signaling receptor activityIDAmolecular_function
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005518collagen bindingNASmolecular_function
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070487monocyte aggregationIMPbiological_process
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0007160cell-matrix adhesionNASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0030212hyaluronan metabolic processTASbiological_process
GO:1900625positive regulation of monocyte aggregationIMPbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0034116positive regulation of heterotypic cell-cell adhesIMPbiological_process
GO:0060442branching involved in prostate gland morphogenesisIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0005540hyaluronic acid bindingIEAmolecular_function
GO:0002246wound healing involved in inflammatory responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051216cartilage developmentIEPbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0043518negative regulation of DNA damage response, signalIDAbiological_process
GO:0004415hyalurononglucosaminidase activityIDAmolecular_function