| UniProt/SwissProt ID: | HAS2_HUMAN |
| Description: | hyaluronan synthase 2 [Source:HGNC Symbol;Acc:4819] |
| Location: | chr8 q24.13 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T110 | SVKRLtYPGIK | Glycos_transf_2 | PhosphoSitePlus |
| Y546 | KKGQQyDMVLD | PhosphoSitePlus | |
| T412 | LLFLLtVQLVG | TM; Chitin_synth_2 | PhosphoSitePlus |
| Dephosphorylation site |
| HAS2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306991 | A200T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306991 | W148* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306991 | G491C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306991 | W187C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306991 | G139V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| HAS2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HAS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HAS2_HUMAN | CD44_HUMAN | ligand -> receptor | HPMR |
| HAS2_HUMAN | HMMR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| HAS2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035810 | positive regulation of urine volume | IEA | biological_process |
| GO:0001822 | kidney development | ISS | biological_process |
| GO:0070295 | renal water absorption | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IMP | biological_process |
| GO:0036120 | cellular response to platelet-derived growth facto | IDA | biological_process |
| GO:0001822 | kidney development | IEA | biological_process |
| GO:0050501 | hyaluronan synthase activity | ISS | molecular_function |
| GO:0071356 | cellular response to tumor necrosis factor | IEP | biological_process |
| GO:0050501 | hyaluronan synthase activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | IDA | cellular_component |
| GO:0071347 | cellular response to interleukin-1 | IEP | biological_process |
| GO:0070295 | renal water absorption | ISS | biological_process |
| GO:0071498 | cellular response to fluid shear stress | IEP | biological_process |
| GO:2000147 | positive regulation of cell motility | IMP | biological_process |
| GO:0030213 | hyaluronan biosynthetic process | ISS | biological_process |
| GO:1900625 | positive regulation of monocyte aggregation | IMP | biological_process |
| GO:0016758 | transferase activity, transferring hexosyl groups | IEA | molecular_function |
| GO:0035810 | positive regulation of urine volume | ISS | biological_process |