Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HAS2_HUMAN
Description:hyaluronan synthase 2 [Source:HGNC Symbol;Acc:4819]
Location:chr8 q24.13
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T110SVKRLtYPGIKGlycos_transf_2PhosphoSitePlus
Y546KKGQQyDMVLDPhosphoSitePlus
T412LLFLLtVQLVGTM; Chitin_synth_2PhosphoSitePlus

Dephosphorylation site
HAS2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306991A200TCOSMICOvarian Cancer21720365
ENSP00000306991W148*COSMICOvarian Cancer21720365
ENSP00000306991G491CCOSMICOvarian Cancer21720365
ENSP00000306991W187CCOSMICOvarian Cancer21720365
ENSP00000306991G139VCOSMICOvarian Cancer21720365

Differential expressed protein
HAS2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HAS2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HAS2_HUMANCD44_HUMANligand -> receptorHPMR
HAS2_HUMANHMMR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
HAS2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035810positive regulation of urine volumeIEAbiological_process
GO:0001822kidney developmentISSbiological_process
GO:0070295renal water absorptionIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0036120cellular response to platelet-derived growth factoIDAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0050501hyaluronan synthase activityISSmolecular_function
GO:0071356cellular response to tumor necrosis factorIEPbiological_process
GO:0050501hyaluronan synthase activityIEAmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0070295renal water absorptionISSbiological_process
GO:0071498cellular response to fluid shear stressIEPbiological_process
GO:2000147positive regulation of cell motilityIMPbiological_process
GO:0030213hyaluronan biosynthetic processISSbiological_process
GO:1900625positive regulation of monocyte aggregationIMPbiological_process
GO:0016758transferase activity, transferring hexosyl groupsIEAmolecular_function
GO:0035810positive regulation of urine volumeISSbiological_process


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