| UniProt/SwissProt ID: | CD33_HUMAN |
| Description: | CD33 molecule [Source:HGNC Symbol;Acc:1659] |
| Location: | chr19 q13.41 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y358 | DTSTEySEVRT | PhosphoSitePlus; RegPhos | |
| S248 | FPGDGsGKQET | DUF998 | PhosphoSitePlus |
| Y340 | DEELHyASLNF | Src | RegPhos |
| Y340 | DEELHyASLNF | SRC | HPRD; phosphoELM; RegPhos |
| Y340 | DEELHyASLNF | Lck | phosphoELM; RegPhos |
| T302 | NDTHPtTGSAS | PhosphoSitePlus | |
| T239 | VPQNPtTGIFP | DUF998 | PhosphoSitePlus |
| Y340 | DEELHyASLNF | PhosphoSitePlus; phosphoELM; RegPhos | |
| T226 | VTTERtIQLNV | PhosphoSitePlus | |
| T363 | YSEVRtQ____ | PhosphoSitePlus | |
| Y358 | DTSTEySEVR | phosphoELM | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y340 | EMDEELHyASLNFHG | PTPN6 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262262 | M17I | COSMIC | Skin Cancer | 21984974 | ENSP00000262262 | P46H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000262262 | Q228H | BIOMART | Brain Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CD33_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD33_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRC_HUMAN | CD33_HUMAN | kinase -> substrate | HPRD; RegPhos |
| LCK_HUMAN | CD33_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | CD33_HUMAN | kinase -> substrate | RegPhos |
| PTN6_HUMAN | CD33_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |