Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCND3_HUMAN
Description:cyclin D3 [Source:HGNC Symbol;Acc:1585]
Location:chr6 p21.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T283PSQTStPTDVTGSK-3_betaphosphoELM
S264SQTSSsPAPKACyclin_CPhosphoSitePlus
S263ASQTSsSPAPKCyclin_CPhosphoSitePlus
S282GPSQTsTPTDVPhosphoSitePlus
S263ASQTSsSPAPKHPRD; phosphoELM
T283PSQTStPTDVTGSK3B(GSK3 betaRegPhos
T281QGPSQtSTPTDPhosphoSitePlus
T9LCCEGtRHAPRPhosphoSitePlus
S264SQTSSsPAPKAHPRD; phosphoELM
T283PSQTStPTDVTPhosphoSitePlus
T261REASQtSSSPACyclin_CPhosphoSitePlus
S279SSQGPsQTSTPCyclin_CPhosphoSitePlus

Dephosphorylation site
CCND3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362082R172CCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000362082Neoplasms by Histologic TypeCancer vs. Cancer (progression)tissueUp15098007

Hyperphosphorylation site
CCND3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANCCND3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SP1_HUMANCCND3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa05166HTLV-I infection
hsa04115p53 signaling pathway
hsa05162Measles
hsa05203Viral carcinogenesis
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045737positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051726regulation of cell cycleIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0000307cyclin-dependent protein kinase holoenzyme complexIDAcellular_component
GO:0042098T cell proliferationIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0051301cell divisionIEAbiological_process


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