Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMP4_HUMAN
Description:bone morphogenetic protein 4 [Source:HGNC Symbol;Acc:1071]
Location:chr14 q22.2
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y82AVIPDyMRDLYTGFb_propeptidePhosphoSitePlus
S119ANTVRsFHHEETGFb_propeptidePhosphoSitePlus
T116ASRANtVRSFHTGFb_propeptidePhosphoSitePlus

Dephosphorylation site
BMP4_HUMAN do not have dephosphorylation site.

Mutation site
BMP4_HUMAN do not have mutation site.

Differential expressed protein
BMP4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMP4_HUMANBMPR2_HUMANligand -> receptorHPMR
BMP4_HUMANBMR1B_HUMANligand -> receptorHPMR
BMP4_HUMANBMR1A_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0003014renal system processIEAbiological_process
GO:0072101specification of ureteric bud anterior/posterior sIDAbiological_process
GO:2001012mesenchymal cell differentiation involved in renalIEAbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0030224monocyte differentiationIDAbiological_process
GO:0072097negative regulation of branch elongation involved IDAbiological_process
GO:0007500mesodermal cell fate determinationIEAbiological_process
GO:0070244negative regulation of thymocyte apoptotic processIMPbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIDAbiological_process
GO:0060512prostate gland morphogenesisIEAbiological_process
GO:0003279cardiac septum developmentTASbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0061149BMP signaling pathway involved in ureter morphogenIEAbiological_process
GO:0060686negative regulation of prostatic bud formationIEAbiological_process
GO:0060440trachea formationIEAbiological_process
GO:0002320lymphoid progenitor cell differentiationIMPbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0040007growthIEAbiological_process
GO:0072198mesenchymal cell proliferation involved in ureter IEAbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0045843negative regulation of striated muscle tissue deveIDAbiological_process
GO:0042476odontogenesisIGIbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0048754branching morphogenesis of a tubeIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:2000137negative regulation of cell proliferation involvedIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060393regulation of pathway-restricted SMAD protein phosIDAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIDAbiological_process
GO:0060684epithelial-mesenchymal cell signalingIEAbiological_process
GO:0032331negative regulation of chondrocyte differentiationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0060449bud elongation involved in lung branchingIEAbiological_process
GO:0009888tissue developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0060503bud dilation involved in lung branchingIDAbiological_process
GO:0033088negative regulation of immature T cell proliferatiIMPbiological_process
GO:0043407negative regulation of MAP kinase activityIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048286lung alveolus developmentIDAbiological_process
GO:0007224smoothened signaling pathwayIEPbiological_process
GO:0070700BMP receptor bindingIDAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0030501positive regulation of bone mineralizationIDAbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0072125negative regulation of glomerular mesangial cell pIDAbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0001823mesonephros developmentIEPbiological_process
GO:0090194negative regulation of glomerulus developmentIDAbiological_process
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:0021537telencephalon developmentIDAbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0001657ureteric bud developmentIDAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0003139secondary heart field specificationIMPbiological_process
GO:0071893BMP signaling pathway involved in nephric duct forIDAbiological_process
GO:0048745smooth muscle tissue developmentISSbiological_process
GO:0060272embryonic skeletal joint morphogenesisIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0021978telencephalon regionalizationIEAbiological_process
GO:0034504protein localization to nucleusIDAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0072193ureter smooth muscle cell differentiationIEAbiological_process
GO:0045839negative regulation of mitosisIDAbiological_process
GO:0060502epithelial cell proliferation involved in lung morIDAbiological_process
GO:2000007negative regulation of metanephric comma-shaped boIDAbiological_process
GO:0090191negative regulation of branching involved in ureteIDAbiological_process
GO:0055020positive regulation of cardiac muscle fiber develoIMPbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0003130BMP signaling pathway involved in heart inductionIMPbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0048333mesodermal cell differentiationIEAbiological_process
GO:0042326negative regulation of phosphorylationIDAbiological_process
GO:0035990tendon cell differentiationIEAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:2000005negative regulation of metanephric S-shaped body mIDAbiological_process
GO:0003323type B pancreatic cell developmentIDAbiological_process
GO:0060429epithelium developmentIEAbiological_process
GO:0060438trachea developmentIDAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0002244hematopoietic progenitor cell differentiationIDAbiological_process
GO:0048660regulation of smooth muscle cell proliferationIEAbiological_process
GO:0072138mesenchymal cell proliferation involved in ureteriIEAbiological_process
GO:0045662negative regulation of myoblast differentiationIDAbiological_process
GO:0001822kidney developmentIMPbiological_process
GO:0009948anterior/posterior axis specificationIEAbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0042487regulation of odontogenesis of dentin-containing tIEAbiological_process
GO:0061047positive regulation of branching involved in lung IEAbiological_process
GO:0060363cranial suture morphogenesisIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0060197cloacal septationIEAbiological_process
GO:0009791post-embryonic developmentIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0030225macrophage differentiationIDAbiological_process
GO:0035993deltoid tuberosity developmentIEAbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0033085negative regulation of T cell differentiation in tIMPbiological_process
GO:0072104glomerular capillary formationIEAbiological_process
GO:0060688regulation of morphogenesis of a branching structuIEAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0060687regulation of branching involved in prostate glandIEAbiological_process
GO:0010159specification of organ positionIEAbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0043401steroid hormone mediated signaling pathwayIMPbiological_process
GO:0060592mammary gland formationIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIDAbiological_process
GO:0060235lens induction in camera-type eyeIEAbiological_process
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0051150regulation of smooth muscle cell differentiationIEAbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0060425lung morphogenesisIDAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0072161mesenchymal cell differentiation involved in kidneIEAbiological_process
GO:0005125cytokine activityIDAmolecular_function
GO:0072001renal system developmentIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0061155pulmonary artery endothelial tube morphogenesisIDAbiological_process
GO:0001649osteoblast differentiationIDAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0060348bone developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0030509BMP signaling pathwayIMPbiological_process
GO:0048392intermediate mesodermal cell differentiationIDAbiological_process
GO:0045778positive regulation of ossificationIDAbiological_process
GO:0001958endochondral ossificationIEAbiological_process
GO:0060433bronchus developmentIDAbiological_process
GO:0072001renal system developmentIEPbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0060113inner ear receptor cell differentiationIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0060548negative regulation of cell deathIDAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0005576extracellular regionISScellular_component
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0048661positive regulation of smooth muscle cell proliferIDAbiological_process
GO:0003197endocardial cushion developmentTASbiological_process
GO:0090184positive regulation of kidney developmentIDAbiological_process
GO:0010942positive regulation of cell deathIDAbiological_process
GO:0048593camera-type eye morphogenesisIEAbiological_process
GO:0060442branching involved in prostate gland morphogenesisIEAbiological_process
GO:0002043blood vessel endothelial cell proliferation involvIDAbiological_process
GO:0072015glomerular visceral epithelial cell developmentIEAbiological_process
GO:0048706embryonic skeletal system developmentIEAbiological_process
GO:0061151BMP signaling pathway involved in renal system segIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0072200negative regulation of mesenchymal cell proliferatIDAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0003337mesenchymal to epithelial transition involved in mIDAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0045603positive regulation of endothelial cell differentiIEAbiological_process
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0072192ureter epithelial cell differentiationIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0061035regulation of cartilage developmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0072205metanephric collecting duct developmentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIDAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:2000105positive regulation of DNA-dependent DNA replicatiIDAbiological_process
GO:0061036positive regulation of cartilage developmentIDAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0060391positive regulation of SMAD protein import into nuIDAbiological_process
GO:0010595positive regulation of endothelial cell migrationIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process