| UniProt/SwissProt ID: | BLNK_HUMAN |
| Description: | B-cell linker [Source:HGNC Symbol;Acc:14211] |
| Location: | chrHG339_PATCH q24.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T254 | GKKPTtPLKTT | PhosphoSitePlus | |
| Y84 | SDSEMyVMPAE | Syk | RegPhos |
| Y72 | DFDSDyENPDE | PhosphoSitePlus; RegPhos | |
| Y96 | NADDSyEPPPV | Syk | RegPhos |
| Y178 | EDEADyVVPVE | SYK | phosphoELM |
| Y96 | NADDSyEPPPV | SYK | phosphoELM |
| Y178 | EDEADyVVPVE | Syk | RegPhos |
| Y178 | EDEADyVVPVE | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y84 | SDSEMyVMPAE | SYK | phosphoELM |
| Y96 | NADDSyEPPPV | PhosphoSitePlus; RegPhos | |
| Y189 | DNDENyIHPTE | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y72 | DFDSDyENPDE | SYK | phosphoELM |
| Y84 | SDSEMyVMPAE | PhosphoSitePlus; RegPhos | |
| Y72 | DFDSDyENPDE | Syk | RegPhos |
| Dephosphorylation site |
| BLNK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000224337 | V180I | COSMIC | Melanoma | 21499247 | ENSP00000224337 | S129F | COSMIC | Melanoma | 21499247 | ENSP00000360218 | *434Y | COSMIC | Ovarian Cancer | 20826764 |
| Differential expressed protein |
| BLNK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BLNK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | BLNK_HUMAN | kinase -> substrate | RegPhos |
| KSYK_HUMAN | BLNK_HUMAN | kinase -> substrate | KEGG; NetPath; Robert H Newman (2013) |
| PTN6_HUMAN | BLNK_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04662 | B cell receptor signaling pathway |
| hsa05340 | Primary immunodeficiency |
| hsa04380 | Osteoclast differentiation |
| hsa04064 | NF-kappa B signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | TAS | biological_process |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0005622 | intracellular | NAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005068 | transmembrane receptor protein tyrosine kinase ada | TAS | molecular_function |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005070 | SH3/SH2 adaptor activity | RCA | molecular_function |
| GO:0030183 | B cell differentiation | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |