Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	AXIN1_HUMAN
Description:	axin 1 [Source:HGNC Symbol;Acc:903]
Location:	chr16 p13.3
Node attribute:	substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S614	AESGKsASTEV		PhosphoSitePlus
T60	ETSTAtPRRSD		PhosphoSitePlus
S493	GPGHRsPDSGH		HPRD
S611	AKKAEsGKSAS		PhosphoSitePlus
T481	QRVLRtPGRQS	Axin_b-cat_bind	PhosphoSitePlus
S77	PEGSAsPTPPY		PhosphoSitePlus; HPRD; phosphoELM
Y796	GEPIPyRTLVR	DIX	PhosphoSitePlus
T79	GSASPtPPYLK		PhosphoSitePlus
Y148	AIYRKyILDNN	RGS	PhosphoSitePlus
T617	GKSAStEVPGA		PhosphoSitePlus
Y148	AIYRKyILDNN		HPRD
S623	EVPGAsEDAEK		PhosphoSitePlus
Y788	IVVAYyFCGEP	DIX	PhosphoSitePlus
S217	RTGSEsPKVCS		PhosphoSitePlus; HPRD; phosphoELM
Y787	SIVVAyYFCGE	DIX	PhosphoSitePlus
S614	AESGKsASTEV	GSK3B	HPRD
S493	GPGHRsPDSGH	Axin_b-cat_bind	PhosphoSitePlus
S616	SGKSAsTEVPG		PhosphoSitePlus
S469	EENPEsILDEH	Axin_b-cat_bind	PhosphoSitePlus
S486	TPGRQsPGPGH	Axin_b-cat_bind	PhosphoSitePlus
T160	IVSRQtKPATK	RGS	PhosphoSitePlus
Y82	SPTPPyLKWAE		PhosphoSitePlus
T213	LEYTRtGSESP		HPRD; phosphoELM
S75	YEPEGsASPTP		PhosphoSitePlus
T160	IVSRQtKPATK		HPRD

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S222	SESPKVCsDQSSGSG	PPP1CA	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000262320	R533*	COSMIC	Hepatocellular Carcinoma
ENSP00000346935	C249F	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000262320	C249F	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000262320	E73K	COSMIC	Breast Cancer	20668451
ENSP00000262320	P345L	HPI	Hepatocellular Carcinoma	12101426
ENSP00000346935	T649P	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000262320	G425S	HPI	Hepatocellular Carcinoma	12101426
ENSP00000262320	L106R	HPI	Hepatocellular Carcinoma	12101426
ENSP00000262320	T649P	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000262320	G650S	HPI	Hepatocellular Carcinoma	12101426

Differential expressed protein

AXIN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

AXIN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
GSK3B_HUMAN	AXIN1_HUMAN	kinase -> substrate	HPRD
PP1A_HUMAN	AXIN1_HUMAN	phosphatase -> substrate	HPRD
PP2AA_HUMAN	AXIN1_HUMAN	phosphatase -> substrate	NetPath

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05217	Basal cell carcinoma
hsa05200	Pathways in cancer
hsa04310	Wnt signaling pathway
hsa05213	Endometrial cancer
hsa05210	Colorectal cancer

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0008219	cell death	IBA	biological_process
GO:0045732	positive regulation of protein catabolic process	IC	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0046330	positive regulation of JNK cascade	IEA	biological_process
GO:0071514	genetic imprinting	IEA	biological_process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular_component
GO:0007257	activation of JUN kinase activity	IBA	biological_process
GO:0006913	nucleocytoplasmic transport	IEA	biological_process
GO:0016055	Wnt receptor signaling pathway	IEA	biological_process
GO:0070412	R-SMAD binding	IEA	molecular_function
GO:0001932	regulation of protein phosphorylation	IEA	biological_process
GO:0060272	embryonic skeletal joint morphogenesis	IBA	biological_process
GO:0030178	negative regulation of Wnt receptor signaling path	IEA	biological_process
GO:0035412	regulation of catenin import into nucleus	IEA	biological_process
GO:0008022	protein C-terminus binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0048320	axial mesoderm formation	IEA	biological_process
GO:0035412	regulation of catenin import into nucleus	IBA	biological_process
GO:0043547	positive regulation of GTPase activity	IBA	biological_process
GO:0019904	protein domain specific binding	IEA	molecular_function
GO:0090090	negative regulation of canonical Wnt receptor sign	IEA	biological_process
GO:0032947	protein complex scaffold	IMP	molecular_function
GO:0005881	cytoplasmic microtubule	IEA	cellular_component
GO:0014069	postsynaptic density	IEA	cellular_component
GO:0030877	beta-catenin destruction complex	IEA	cellular_component
GO:0051248	negative regulation of protein metabolic process	IEA	biological_process
GO:0043623	cellular protein complex assembly	IDA	biological_process
GO:0044459	plasma membrane part	IEA	cellular_component
GO:0005096	GTPase activator activity	IBA	molecular_function
GO:0070016	armadillo repeat domain binding	ISS	molecular_function
GO:0031410	cytoplasmic vesicle	IEA	cellular_component
GO:0031122	cytoplasmic microtubule organization	IEA	biological_process
GO:0031398	positive regulation of protein ubiquitination	IEA	biological_process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular_function
GO:0090090	negative regulation of canonical Wnt receptor sign	IBA	biological_process
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005938	cell cortex	IEA	cellular_component
GO:2000060	positive regulation of protein ubiquitination invo	ISS	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:2000060	positive regulation of protein ubiquitination invo	IEA	biological_process
GO:0016023	cytoplasmic membrane-bounded vesicle	IBA	cellular_component
GO:0051443	positive regulation of ubiquitin-protein ligase ac	IMP	biological_process
GO:0030877	beta-catenin destruction complex	IDA	cellular_component
GO:0043507	positive regulation of JUN kinase activity	IEA	biological_process
GO:0048048	embryonic eye morphogenesis	IBA	biological_process
GO:0051260	protein homooligomerization	IEA	biological_process
GO:0009950	dorsal/ventral axis specification	IBA	biological_process
GO:0032436	positive regulation of proteasomal ubiquitin-depen	IEA	biological_process
GO:0014069	postsynaptic density	IBA	cellular_component
GO:0036342	post-anal tail morphogenesis	IEA	biological_process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological_process
GO:0034244	negative regulation of transcription elongation fr	IEA	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	IEA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0030511	positive regulation of transforming growth factor	IEA	biological_process
GO:0019901	protein kinase binding	ISS	molecular_function
GO:0042802	identical protein binding	IEA	molecular_function
GO:0016328	lateral plasma membrane	IDA	cellular_component
GO:0031625	ubiquitin protein ligase binding	IEA	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0071407	cellular response to organic cyclic compound	IBA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0008013	beta-catenin binding	IEA	molecular_function
GO:0001934	positive regulation of protein phosphorylation	IEA	biological_process
GO:0030163	protein catabolic process	IEA	biological_process
GO:0038032	termination of G-protein coupled receptor signalin	IEA	biological_process
GO:0009950	dorsal/ventral axis specification	IEA	biological_process
GO:0070411	I-SMAD binding	IEA	molecular_function
GO:0046330	positive regulation of JNK cascade	ISS	biological_process
GO:0031398	positive regulation of protein ubiquitination	IDA	biological_process
GO:0007605	sensory perception of sound	IEA	biological_process
GO:0033138	positive regulation of peptidyl-serine phosphoryla	IDA	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	IC	biological_process
GO:0005881	cytoplasmic microtubule	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0043234	protein complex	IEA	cellular_component
GO:0001743	optic placode formation	IBA	biological_process
GO:0030178	negative regulation of Wnt receptor signaling path	IDA	biological_process
GO:0002039	p53 binding	IDA	molecular_function
GO:0030910	olfactory placode formation	IBA	biological_process
GO:0000209	protein polyubiquitination	IEA	biological_process
GO:0060823	canonical Wnt receptor signaling pathway involved	IBA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0001701	in utero embryonic development	IEA	biological_process
GO:0031410	cytoplasmic vesicle	ISS	cellular_component
GO:0021881	Wnt receptor signaling pathway involved in forebra	IBA	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0021797	forebrain anterior/posterior pattern specification	IBA	biological_process
GO:0070016	armadillo repeat domain binding	IEA	molecular_function
GO:0045599	negative regulation of fat cell differentiation	IEA	biological_process
GO:0007275	multicellular organismal development	IEA	biological_process
GO:0031122	cytoplasmic microtubule organization	IBA	biological_process
GO:0032147	activation of protein kinase activity	IDA	biological_process
GO:0007368	determination of left/right symmetry	IBA	biological_process
GO:0042802	identical protein binding	ISS	molecular_function
GO:0045860	positive regulation of protein kinase activity	IEA	biological_process
GO:0005886	plasma membrane	IDA	cellular_component
GO:0048318	axial mesoderm development	IEA	biological_process
GO:0045599	negative regulation of fat cell differentiation	IBA	biological_process
GO:0090244	Wnt receptor signaling pathway involved in somitog	IBA	biological_process
GO:0042803	protein homodimerization activity	IEA	molecular_function
GO:0045893	positive regulation of transcription, DNA-dependen	IMP	biological_process
GO:0048320	axial mesoderm formation	IBA	biological_process
GO:0005938	cell cortex	IBA	cellular_component
GO:0004871	signal transducer activity	IDA	molecular_function
GO:0043621	protein self-association	IEA	molecular_function
GO:0070411	I-SMAD binding	IPI	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0046332	SMAD binding	IPI	molecular_function
GO:0055001	muscle cell development	IBA	biological_process
GO:0010800	positive regulation of peptidyl-threonine phosphor	IDA	biological_process
GO:0071944	cell periphery	IDA	cellular_component
GO:0008013	beta-catenin binding	IDA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network