Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATF6A_HUMAN
Description:activating transcription factor 6 [Source:HGNC Symbol;Acc:791]
Location:chr1 q23.3
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T296PVLQStMRNVGPhosphoSitePlus
S373RLKVPsPKRRVPhosphoSitePlus
S632HIKSSsVPPYLPhosphoSitePlus
T565RRRGDtFYVVSPhosphoSitePlus
Y330KKKKEyMLGLEbZIP_1PhosphoSitePlus

Dephosphorylation site
ATF6A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356919L470VCOSMICOvarian Cancer21720365
ENSP00000356919K327NBIOMARTBreast Cancer21930507, 21930502
ENSP00000356919L470VTCGAOvarian Cancer21720365, 18772890
ENSP00000356919I471TTCGAOvarian Cancer21720365, 18772890
ENSP00000356919G6RTCGAOvarian Cancer21720365, 18772890
ENSP00000356919I471TCOSMICOvarian Cancer21720365
ENSP00000356919G6RCOSMICOvarian Cancer21720365
ENSP00000356919R317*COSMICMelanoma21499247

Differential expressed protein
ATF6A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ATF6A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2A_HUMANATF6A_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANATF6A_HUMANkinase -> substrateRobert H Newman (2013)
PSN1_HUMANATF6A_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0006990positive regulation of transcription from RNA polyTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006950response to stressTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005635nuclear envelopeTAScellular_component
GO:0006457protein foldingTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0000139Golgi membraneTAScellular_component


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