| UniProt/SwissProt ID: | ATF6A_HUMAN |
| Description: | activating transcription factor 6 [Source:HGNC Symbol;Acc:791] |
| Location: | chr1 q23.3 |
| Node attribute: | substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T296 | PVLQStMRNVG | PhosphoSitePlus | |
| S373 | RLKVPsPKRRV | PhosphoSitePlus | |
| S632 | HIKSSsVPPYL | PhosphoSitePlus | |
| T565 | RRRGDtFYVVS | PhosphoSitePlus | |
| Y330 | KKKKEyMLGLE | bZIP_1 | PhosphoSitePlus |
| Dephosphorylation site |
| ATF6A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356919 | L470V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356919 | K327N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356919 | L470V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356919 | I471T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356919 | G6R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356919 | I471T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356919 | G6R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356919 | R317* | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| ATF6A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ATF6A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC2A_HUMAN | ATF6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | ATF6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PSN1_HUMAN | ATF6A_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05010 | Alzheimer's disease |
| hsa04141 | Protein processing in endoplasmic reticulum |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006990 | positive regulation of transcription from RNA poly | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005635 | nuclear envelope | TAS | cellular_component |
| GO:0006457 | protein folding | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006987 | activation of signaling protein activity involved | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0030968 | endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0000139 | Golgi membrane | TAS | cellular_component |