Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHGB_HUMAN
Description:Rho guanine nucleotide exchange factor (GEF) 11 [Source:HGNC Symbol;Acc:14580]
Location:chr1 q23.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T294LDSPRtSPVIMHPRD
T708SLENPtPPFTPHPRD
S29ERKSPsHHRQPPhosphoSitePlus
S1497SLGGEsSGGTTHPRD
S1295PRTRNsGIWESPhosphoSitePlus; HPRD; phosphoELM
S1491PLASDsRNSHEHPRD; phosphoELM
S1457SLGGEsSGGTTPhosphoSitePlus; HPRD; phosphoELM
T672PTPPFtPKMGRPhosphoSitePlus; HPRD; phosphoELM
S675VPRSRsDVDMDHPRD
T1515EAARWtDGSLSHPRD
S285RNSVLsDPGLDHPRD
S614LGRSEsLKGREPhosphoSitePlus
T1475EAARWtDGSLSPhosphoSitePlus; HPRD; phosphoELM
S663SLSTRsLENPTPhosphoSitePlus; HPRD; phosphoELM
S1466TTPVGsFHTEAHPRD; phosphoELM
S1529KEPLAsDSRNSHPRD
T712PTPPFtPKMGRHPRD
T1063ELVALtSSDKNPhosphoSitePlus
S429TLGLGsLYGENRGS-likePhosphoSitePlus
S1480TDGSLsPPAKEPhosphoSitePlus; HPRD; phosphoELM
S271HRRQGsDAAVPPhosphoSitePlus
S1064LVALTsSDKNTPhosphoSitePlus
S1155PEQEGsAEEEEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S291DPGLDsPRTSPHPRD
T1502SSGGTtPVGSFHPRD
S1300SGIWEsPELDRPhosphoSitePlus; HPRD; phosphoELM
S1489KEPLAsDSRNSHPRD; phosphoELM
S556FHIPLsPVEVKPhosphoSitePlus
T1501ESSGGtTPVGSHPRD
T41DASETtGLVQRPhosphoSitePlus
S1335PRTRNsGIWESHPRD
S589GTQRLsTGSFPPhosphoSitePlus
S635VPRSRsDVDMDPhosphoSitePlus; HPRD
S35HHRQPsDASETPhosphoSitePlus; HPRD
S245RNSVLsDPGLDPhosphoSitePlus; HPRD; phosphoELM
S255DSPRTsPVIMAPhosphoSitePlus; HPRD; phosphoELM
T40SDASEtTGLVQPhosphoSitePlus
S1458LGGESsGGTTPPhosphoSitePlus; HPRD; phosphoELM
S1520TDGSLsPPAKEHPRD
S1340SGIWEsPELDRHPRD
T1461ESSGGtTPVGSPhosphoSitePlus; HPRD; phosphoELM
S1498LGGESsGGTTPHPRD
S38QPSDAsETTGLPhosphoSitePlus
S1195PEQEGsAEEEEHPRD
T254LDSPRtSPVIMPhosphoSitePlus; HPRD; phosphoELM
S27APERKsPSHHRPhosphoSitePlus
S592RLSTGsFPEDLPhosphoSitePlus
S251DPGLDsPRTSPPhosphoSitePlus; HPRD; phosphoELM
S1065VALTSsDKNTWPhosphoSitePlus
S1506TTPVGsFHTEAHPRD
S1478RWTDGsLSPPAPhosphoSitePlus
S703SLSTRsLENPTHPRD
S1531PLASDsRNSHEHPRD
S295DSPRTsPVIMAHPRD
T668SLENPtPPFTPPhosphoSitePlus; HPRD; phosphoELM
T1462SSGGTtPVGSFPhosphoSitePlus; HPRD; phosphoELM
S1312R.NLAEDASSTEAAGGYKVVRK.ASysPTM 2.0

Dephosphorylation site
ARHGB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357177R246SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000357177I1096LCOSMICPancreatic Cancer
ENSP00000357177D1350NCOSMICOvarian Cancer21720365
ENSP00000357177R702TCOSMICOvarian Cancer21720365
ENSP00000357177H1133YCOSMICSkin Cancer21984974
ENSP00000357177T1002KCOSMICSkin Cancer21984974
ENSP00000357177F382LCOSMICMelanoma21499247
ENSP00000354644R206SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000354644V243IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000357177P1276SCOSMICLung Cancer

Differential expressed protein
ARHGB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARHGB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA13_HUMANARHGB_HUMANGprotein -> effectorgpDB
GNAQ_HUMANARHGB_HUMANGprotein -> effectorgpDB
GNA12_HUMANARHGB_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006928cellular component movementNASbiological_process
GO:0006941striated muscle contractionNASbiological_process
GO:0005829cytosolTAScellular_component
GO:0007266Rho protein signal transductionIDAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0030010establishment of cell polarityNASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005096GTPase activator activityIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005622intracellularICcellular_component
GO:0005089Rho guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0000910cytokinesisNASbiological_process
GO:0001558regulation of cell growthNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0030036actin cytoskeleton organizationNASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0001664G-protein coupled receptor bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process


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