Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHG1_HUMAN
Description:Rho guanine nucleotide exchange factor (GEF) 1 [Source:HGNC Symbol;Acc:681]
Location:chr19 q13.2
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S743PKPRPsPSSTRHPRD
S863GGGPLsPARTQPhosphoSitePlus; HPRD; phosphoELM
S25ARGAAsPGPSRHPRD
S29ASPGPsRPGLVHPRD
S798GGRETsPADARPhosphoSitePlus; HPRD
S878GGGPLsPARTQHPRD
Y487RQESGyLIEEIRhoGEFPhosphoSitePlus
S10ARGAAsPGPSRPhosphoSitePlus; HPRD; phosphoELM
S14ASPGPsRPGLVHPRD; phosphoELM
S788PLLSSsENGNGPhosphoSitePlus
T695HSRTLtPTPDGPhosphoSitePlus
S240SGDKKsGRNFFPhosphoSitePlus
S830GGGPLsPARTQHPRD
S776PKPRPsPSSTRHPRD
S631HLRQSsDPMLSPhosphoSitePlus
S786REPLLsSSENGPhosphoSitePlus
S813GGRETsPADARHPRD
S765GGRETsPADARHPRD
S791PKPRPsPSSTRHPRD
Y738QEAQIyELVAQPhosphoSitePlus

Dephosphorylation site
ARHG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346532M165VHPIColorectal Cancer16959974
ENSP00000337261V452MCOSMICSkin Cancer21984974
ENSP00000337261S3TCOSMICOvarian Cancer21720365
ENSP00000337261V165MSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000337261A76TCOSMICOvarian Cancer21720365
ENSP00000337261R247QCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000346532Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineDown0.3818654985

Hyperphosphorylation site
ARHG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA12_HUMANARHG1_HUMANGprotein -> effectorgpDB
GNA13_HUMANARHG1_HUMANGprotein -> effectorgpDB
GNAQ_HUMANARHG1_HUMANGprotein -> effectorgpDB
KPCA_HUMANARHG1_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005096GTPase activator activityIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0007266Rho protein signal transductionTASbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0050771negative regulation of axonogenesisTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0050770regulation of axonogenesisTASbiological_process
GO:0005622intracellularIEAcellular_component


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