Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APBB1_HUMAN
Description:amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) [Source:HGNC Symbol;Acc:581]
Location:chr11 p15.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S287PPGRAsPSQGSMAPK1phosphoELM
S287PPGRAsPSQGSPhosphoSitePlus
S459GVGRDsGRERDHPRD
Y547KFQVYyLGNVPPIDPhosphoSitePlus
S287PPGRAsPSQGSErk2(MAPK1RegPhos
S347PAQSLsPEPLPPhosphoSitePlus
T709RLGAHtP____PhosphoSitePlus
S175EEDLSsPPGLPSigma70_ner; Nop14PhosphoSitePlus
S175EEDLSsPPGLPErk2(MAPK1RegPhos
T709RLGAHMAPK1phosphoELM
T709RLGAHtPErk2(MAPK1RegPhos
S695RRGVQsLWGSLPhosphoSitePlus
S347PAQSLsPEPLPMAPK1phosphoELM
S459GVGRDsGRERDPIDPhosphoSitePlus
S459GVGRDsGRDFAHPRD
S699QSLWGsLKPKRPhosphoSitePlus
S347PAQSLsPEPLPErk2(MAPK1RegPhos
S175EEDLSsPPGLPMAPK1phosphoELM

Dephosphorylation site
APBB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299402E162KCOSMICBreast Cancer17932254
ENSP00000299402A552TCOSMICBreast Cancer17932254
ENSP00000299402R389CBIOMARTBreast Cancer21930507, 21930502
ENSP00000311912R389CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
APBB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
APBB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANAPBB1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANAPBB1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANAPBB1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
APBB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0005634nucleusISScellular_component
GO:0043967histone H4 acetylationISSbiological_process
GO:0045202synapseIDAcellular_component
GO:0045739positive regulation of DNA repairIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003682chromatin bindingIDAmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0030308negative regulation of cell growthISSbiological_process
GO:0001540beta-amyloid bindingIPImolecular_function
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0045749negative regulation of S phase of mitotic cell cycISSbiological_process
GO:0030426growth coneIDAcellular_component
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0045749negative regulation of S phase of mitotic cell cycIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentISSbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0008134transcription factor bindingISSmolecular_function
GO:0001764neuron migrationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007050cell cycle arrestIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070064proline-rich region bindingIPImolecular_function
GO:0042393histone bindingIPImolecular_function
GO:0050760negative regulation of thymidylate synthase biosynISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0007409axonogenesisNASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007050cell cycle arrestISSbiological_process
GO:0050760negative regulation of thymidylate synthase biosynIEAbiological_process


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