Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANPRA_HUMAN
Description:natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) [Source:HGNC Symbol;Acc:7943]
Location:chr1 q21.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S519DVEPSsLERHLPhosphoSitePlus
S538LSGRGsNYGSLPhosphoSitePlus; HPRD; phosphoELM
S542GSNYGsLLTTEPkinase_TyrPhosphoSitePlus
T532AGSRLtLSGRGPhosphoSitePlus; HPRD; phosphoELM
T545YGSLLtTEGQFHPRD; phosphoELM
S529LRSAGsRLTLSPKA_groupphosphoELM
S711LLRMAsPPVRGPkinase_TyrPhosphoSitePlus
T545YGSLLtTEGQFPkinase_TyrPhosphoSitePlus
T835LVEERtQAYLEHNOBAPhosphoSitePlus
S534SRLTLsGRGSNPhosphoSitePlus; HPRD; phosphoELM
S542GSNYGsLLTTEHPRD; phosphoELM
S505EKELAsELWRVPhosphoSitePlus
S529LRSAGsRLTLSPhosphoSitePlus; HPRD
Y927TIGDAyMVVSGGuanylate_cycPhosphoSitePlus

Dephosphorylation site
ANPRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357669F270CGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000357669G541STCGAOvarian Cancer21720365, 18772890
ENSP00000357669*1062WCOSMICHead and Neck Cancer21798893

Differential expressed protein
ANPRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ANPRA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANF_HUMANANPRA_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007168receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016525negative regulation of angiogenesisTASbiological_process
GO:0030828positive regulation of cGMP biosynthetic processIEAbiological_process
GO:0042417dopamine metabolic processIEAbiological_process
GO:0042312regulation of vasodilationNASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0035815positive regulation of renal sodium excretionTASbiological_process
GO:0035810positive regulation of urine volumeTASbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0042562hormone bindingIPImolecular_function
GO:0007589body fluid secretionTASbiological_process
GO:0008528G-protein coupled peptide receptor activityNASmolecular_function
GO:0006182cGMP biosynthetic processIDAbiological_process
GO:0007166cell surface receptor signaling pathwayNASbiological_process
GO:0016941natriuretic peptide receptor activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0048662negative regulation of smooth muscle cell proliferIEAbiological_process
GO:0004383guanylate cyclase activityIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0043114regulation of vascular permeabilityTASbiological_process
GO:0008217regulation of blood pressureNASbiological_process
GO:0050880regulation of blood vessel sizeIEAbiological_process
GO:0006182cGMP biosynthetic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016941natriuretic peptide receptor activityIDAmolecular_function
GO:0030308negative regulation of cell growthNASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0004383guanylate cyclase activityIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005887integral to plasma membraneICcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function