Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY4_HUMAN
Description:adenylate cyclase 4 [Source:HGNC Symbol;Acc:235]
Location:chr14 q12
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y444LGEPTyLVIDPGuanylate_cycPhosphoSitePlus
T459EDEKGtAGGLLPhosphoSitePlus
S6MARLFsPRPPPPhosphoSitePlus
S253QAGQGsRPESTPhosphoSitePlus

Dephosphorylation site
ADCY4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312126P527LCOSMICSkin Cancer21984974
ENSP00000393177A427TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000312126Q543*COSMICHead and Neck Cancer21798893
ENSP00000312126R450WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000312126P847LCOSMICOvarian Cancer21720365
ENSP00000393177R450WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000312126A427TCOSMICPancreatic Cancer

Differential expressed protein
ADCY4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG5_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG11_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG2_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBB5_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG3_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG1_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG13_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG10_HUMANADCY4_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBB1_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG8_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBB3_HUMANADCY4_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBG12_HUMANADCY4_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04972Pancreatic secretion
hsa04723Retrograde endocannabinoid signaling
hsa04912GnRH signaling pathway
hsa04970Salivary secretion
hsa04976Bile secretion
hsa04020Calcium signaling pathway
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa05166HTLV-I infection
hsa05414Dilated cardiomyopathy
hsa04916Melanogenesis
hsa04971Gastric acid secretion
hsa04270Vascular smooth muscle contraction
hsa04914Progesterone-mediated oocyte maturation
hsa00230Purine metabolism
hsa04742Taste transduction
hsa05032Morphine addiction
hsa04540Gap junction
hsa04724Glutamatergic synapse
hsa04114Oocyte meiosis
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0006833water transportTASbiological_process
GO:0006171cAMP biosynthetic processISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0016020membraneISScellular_component
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0004016adenylate cyclase activityISSmolecular_function
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0016021integral to membraneIEAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23