Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA1A_HUMAN
Description:adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:277]
Location:chr8 p21.2
Node attribute:GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T273KKAAKtLGIVV7tm_1PhosphoSitePlus
T273KKAAKtLGIVVHPRD
S304PDFKPsETVFK7tm_1PhosphoSitePlus
S304PDFKPsETVFKHPRD

Dephosphorylation site
ADA1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369960V128MCOSMICBreast Cancer20668451
ENSP00000369960H256QCOSMICOvarian Cancer21720365
ENSP00000369956G40WBIOMARTBreast Cancer21930507, 21930502
ENSP00000369960G40WCOSMICBreast Cancer16959974
ENSP00000369960P293SCOSMICLung Cancer20668451
ENSP00000276393G40WSjoblom2006, HPIBreast Cancer16959974
ENSP00000369960V311ICOSMICMelanoma20016485

Differential expressed protein
ADA1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ADA1A_HUMANGNA13_HUMANGPCR -> GproteingpDB
ADA1A_HUMANGNA11_HUMANGPCR -> GproteingpDB
ADA1A_HUMANGNAQ_HUMANGPCR -> GproteingpDB
ADA1A_HUMANGNA12_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
hsa04020Calcium signaling pathway
hsa04970Salivary secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032229negative regulation of synaptic transmission, GABAIEAbiological_process
GO:0010460positive regulation of heart rateIEAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0001996positive regulation of heart rate by epinephrine-nIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202activation of phospholipase C activityIEAbiological_process
GO:0003084positive regulation of systemic arterial blood preIEAbiological_process
GO:0035265organ growthIEAbiological_process
GO:0042493response to drugISSbiological_process
GO:0060073micturitionIEAbiological_process
GO:0001997positive regulation of the force of heart contractIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0045907positive regulation of vasoconstrictionISSbiological_process
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0030018Z discIEAcellular_component
GO:0060402calcium ion transport into cytosolIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0031965nuclear membraneIDAcellular_component
GO:0007204elevation of cytosolic calcium ion concentrationISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0032229negative regulation of synaptic transmission, GABAISSbiological_process
GO:0035024negative regulation of Rho protein signal transducIEAbiological_process
GO:0007512adult heart developmentIEAbiological_process
GO:0060452positive regulation of cardiac muscle contractionISSbiological_process
GO:0042493response to drugIEAbiological_process
GO:0004937alpha1-adrenergic receptor activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0035024negative regulation of Rho protein signal transducISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0030315T-tubuleIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0001994norepinephrine-epinephrine vasoconstriction involvIEAbiological_process
GO:0006939smooth muscle contractionTASbiological_process
GO:0016049cell growthIEAbiological_process
GO:0007568agingISSbiological_process
GO:0007202activation of phospholipase C activityISSbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0060452positive regulation of cardiac muscle contractionIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045987positive regulation of smooth muscle contractionIEAbiological_process
GO:0001985negative regulation of heart rate involved in baroIEAbiological_process
GO:0060402calcium ion transport into cytosolISSbiological_process
GO:0009725response to hormone stimulusISSbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016020membraneIEAcellular_component
GO:0045760positive regulation of action potentialISSbiological_process
GO:0045760positive regulation of action potentialIEAbiological_process
GO:0006950response to stressISSbiological_process
GO:0004937alpha1-adrenergic receptor activityISSmolecular_function
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0090037positive regulation of protein kinase C signaling ISSbiological_process
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0097195pilomotor reflexIEAbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0090037positive regulation of protein kinase C signaling IEAbiological_process