| UniProt/SwissProt ID: | ACTC_HUMAN |
| Description: | actin, alpha, cardiac muscle 1 [Source:HGNC Symbol;Acc:143] |
| Location: | chr15 q14 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y190 | RDLTDyLMKIL | Actin | PhosphoSitePlus |
| Y364 | ISKQEyDEAGP | Actin | PhosphoSitePlus |
| T91 | KIWHHtFYNEL | Actin | PhosphoSitePlus |
| T128 | QIMFEtFNVPA | Actin | PhosphoSitePlus |
| S350 | GSILAsLSTFQ | Actin | PhosphoSitePlus |
| T188 | AGRDLtDYLMK | Actin | PhosphoSitePlus |
| S35 | RAVFPsIVGRP | Actin | PhosphoSitePlus |
| T196 | LMKILtERGYS | Actin | PhosphoSitePlus |
| Y93 | WHHTFyNELRV | Actin | PhosphoSitePlus |
| T280 | GIHETtYNSIM | Actin | PhosphoSitePlus |
| S157 | GIVLDsGDGVT | Actin | PhosphoSitePlus |
| S62 | GDEAQsKRGIL | Actin | PhosphoSitePlus |
| S283 | ETTYNsIMKCD | Actin | PhosphoSitePlus |
| T251 | DGQVItIGNER | Actin | PhosphoSitePlus |
| Y71 | ILTLKyPIEHG | Actin | PhosphoSitePlus |
| Y55 | GQKDSyVGDEA | Actin | PhosphoSitePlus |
| S241 | SSLEKsYELPD | Actin | PhosphoSitePlus |
| Y200 | LTERGySFVTT | Actin | PhosphoSitePlus |
| Y171 | PIYEGyALPHA | Actin | PhosphoSitePlus |
| T68 | KRGILtLKYPI | Actin | PhosphoSitePlus |
| T204 | GYSFVtTAERE | Actin | PhosphoSitePlus |
| S54 | MGQKDsYVGDE | Actin | PhosphoSitePlus |
| S325 | TALAPsTMKIK | Actin | PhosphoSitePlus |
| Y296 | IRKDLyANNVL | Actin | PhosphoSitePlus |
| Y242 | SLEKSyELPDG | Actin | PhosphoSitePlus |
| Y168 | HNVPIyEGYAL | Actin | PhosphoSitePlus |
| T306 | LSGGTtMYPGI | Actin | PhosphoSitePlus |
| Y281 | IHETTyNSIMK | Actin | PhosphoSitePlus |
| T79 | EHGIItNWDDM | Actin | PhosphoSitePlus |
| Y308 | GGTTMyPGIAD | Actin | PhosphoSitePlus |
| Y220 | KEKLCyVALDF | Actin | PhosphoSitePlus |
| S201 | TERGYsFVTTA | Actin | PhosphoSitePlus |
| S267 | TLFQPsFIGME | Actin | PhosphoSitePlus |
| T326 | ALAPStMKIKI | Actin | PhosphoSitePlus |
| T320 | MQKEItALAPS | Actin | PhosphoSitePlus |
| Y145 | AVLSLyASGRT | Actin | PhosphoSitePlus |
| Dephosphorylation site |
| ACTC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000290378 | D365N | COSMIC | Skin Cancer | 21984974 | ENSP00000290378 | D246N | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000290378 | E102V | COSMIC | Skin Cancer | 21984974 | ENSP00000290378 | S241G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000290378 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 3.8 | 16230073 |
| Hyperphosphorylation site |
| ACTC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRF_HUMAN | ACTC_HUMAN | TF -> target gene | TRANSFAC |
| SP1_HUMAN | ACTC_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ACTC_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031032 | actomyosin structure organization | IEA | biological_process |
| GO:0017022 | myosin binding | IPI | molecular_function |
| GO:0033275 | actin-myosin filament sliding | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030240 | skeletal muscle thin filament assembly | IEA | biological_process |
| GO:0060047 | heart contraction | IMP | biological_process |
| GO:0055003 | cardiac myofibril assembly | ISS | biological_process |
| GO:0005884 | actin filament | IDA | cellular_component |
| GO:0055008 | cardiac muscle tissue morphogenesis | ISS | biological_process |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0060048 | cardiac muscle contraction | IEA | biological_process |
| GO:0006915 | apoptotic process | ISS | biological_process |
| GO:0030049 | muscle filament sliding | TAS | biological_process |
| GO:0031032 | actomyosin structure organization | ISS | biological_process |
| GO:0031674 | I band | ISS | cellular_component |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0045471 | response to ethanol | IEA | biological_process |
| GO:0030017 | sarcomere | IDA | cellular_component |
| GO:0031674 | I band | IEA | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0055003 | cardiac myofibril assembly | IEA | biological_process |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0030240 | skeletal muscle thin filament assembly | ISS | biological_process |
| GO:0030048 | actin filament-based movement | IDA | biological_process |
| GO:0055008 | cardiac muscle tissue morphogenesis | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0042643 | actomyosin, actin part | IDA | cellular_component |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |