Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTB_HUMAN
Description:actin, beta [Source:HGNC Symbol;Acc:132]
Location:chr7 p22.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S60GDEAQsKRGILActinPhosphoSitePlus
T194LMKILtERGYSActinPhosphoSitePlus
T201RGYSFtTTAERActinPhosphoSitePlus
Y198LTERGySFTTTphosphoELM
T89KIWHHtFYNELActinPhosphoSitePlus
Y166HTVPIyEGYALActinPhosphoSitePlus
T318MQKEItALAPSActinPhosphoSitePlus; SysPTM
T120NREKMtQIMFEActinPhosphoSitePlus
Y188RDLTDyLMKILActinPhosphoSitePlus
Y362ISKQEyDESGPActinPhosphoSitePlus
Y53GQKDSyVGDEAphosphoELM
Y218KEKLCyVALDFHPRD; phosphoELM
S368DESGPsIVHRKActinPhosphoSitePlus
S271FLGMEsCGIHEActinPhosphoSitePlus
S52MGQKDsYVGDEActinPhosphoSitePlus
S365QEYDEsGPSIVActinPhosphoSitePlus
T201RGYSFtTTAERHPRD
Y240SLEKSyELPDGActinPhosphoSitePlus
Y306GGTTMyPGIADActinPhosphoSitePlus
S155GIVMDsGDGVTActinPhosphoSitePlus
T202GYSFTtTAEREActinPhosphoSitePlus
Y294IRKDLyANTVLActinPhosphoSitePlus
Y91WHHTFyNELRVActinPhosphoSitePlus
S199TERGYsFTTTAActinPhosphoSitePlus
T304LSGGTtMYPGIActinPhosphoSitePlus
T249DGQVItIGNERActinPhosphoSitePlus
T303VLSGGtTMYPGActinPhosphoSitePlus
S323TALAPsTMKIKActinPhosphoSitePlus
T186AGRDLtDYLMKActinPhosphoSitePlus
Y294IRKDLyANTVLHPRD; phosphoELM
S33RAVFPsIVGRPActinPhosphoSitePlus
Y198LTERGySFTTTActinPhosphoSitePlus
S239SSLEKsYELPDActinPhosphoSitePlus
T318MQKEItALAPSHPRD; phosphoELM; SysPTM
Y218KEKLCyVALDFActinPhosphoSitePlus
Y91WHHTFyNELRVphosphoELM
T324ALAPStMKIKIActinPhosphoSitePlus
T203YSFTTtAEREIActinPhosphoSitePlus
Y143AVLSLyASGRTActinPhosphoSitePlus
S265ALFQPsFLGMEActinPhosphoSitePlus
S14VVDNGsGMCKAActinPhosphoSitePlus
Y69ILTLKyPIEHGActinPhosphoSitePlus
Y169PIYEGyALPHAActinPhosphoSitePlus
Y53GQKDSyVGDEAActinPhosphoSitePlus
S14VVDNGsGMCKAHPRD
S300ANTVLsGGTTMActinPhosphoSitePlus
S348GSILAsLSTFQActinPhosphoSitePlus
Y306GGTTMyPGIADHPRD

Dephosphorylation site
ACTB_HUMAN do not have dephosphorylation site.

Mutation site
ACTB_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000349960hepatitis B virusNormal vs. CancertissueDown0.4714726492
ENSP00000349960colorectal cancerNormal vs. CancertissueUp3.519098285
ENSP00000349960colorectal cancerNormal vs. CancertissueUp1.415924290
ENSP00000349960Hepatocellular CarcinomaNormal vs. CancertissueDown0.0515759316
ENSP00000349960papillary thyroid carcinomaNormal vs. CancertissueDown0.2316788983
ENSP00000349960follicular thyroid carcinomaNormal vs. CancertissueDown0.4918316623
ENSP00000349960follicular thyroid carcinomaNormal vs. CancertissueDown0.5618316623
ENSP00000349960follicular thyroid carcinomaNormal vs. CancertissueUp1.218316623
ENSP00000349960follicular thyroid carcinomaNormal vs. CancertissueUp1.318316623
ENSP00000349960papillary thyroid carcinomaNormal vs. CancertissueUp1.518665625
ENSP00000349960papillary thyroid carcinomaNormal vs. CancertissueUp2.618665625
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueUp1.619072117
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueDown0.8619072117
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueUp1.419072117
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueDown0.9219072117
ENSP00000349960Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000349960Esophageal CancerNormal vs. CancertissueDown0.4119142970
ENSP00000349960Breast CancerNormal vs. Cancercell lineUp214997480
ENSP00000349960Breast CancerNormal vs. Cancercell lineUp2.514997480
ENSP00000349960Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000349960Breast CancerNormal vs. CancertissueUp>1020005186
ENSP00000349960Breast CancerNormal vs. Cancercell lineUp2.220052998
ENSP00000349960Breast CancerNormal vs. Cancercell lineUp2.620052998
ENSP00000349960Breast CancerNormal vs. Cancercell lineDown0.9620052998
ENSP00000349960Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000349960Breast CancerMetastasiscell lineDown0.4420052998
ENSP00000349960Breast CancerMetastasiscell lineDown0.4720052998
ENSP00000349960Breast CancerNormal vs. CancertissueUp2.420087651
ENSP00000349960Breast CancerNormal vs. CancertissueUp2.920087651
ENSP00000349960Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueUp1.620602252
ENSP00000349960Oral CancerNormal vs. CancertissueUp5.919691830
ENSP00000349960chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.420417730
ENSP00000349960acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp3.917655343
ENSP00000349960acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp5.117655343
ENSP00000349960acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp7.517655343
ENSP00000349960acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown17655343
ENSP00000349960Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineUp2.515169874
ENSP00000349960Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.2216807943
ENSP00000349960Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp216807943
ENSP00000349960Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.5616807943
ENSP00000349960Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.616807943
ENSP00000349960Pancreatic CancerNormal vs. CancertissueUp4.216230073
ENSP00000349960Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504
ENSP00000349960Uterine CancerTreatment (Concurrent chemoradiotherapy-lowly vs. Concurrent chemoradiotherapy-highly sensitive)tissueUp19507834

Hyperphosphorylation site
ACTB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRF_HUMANACTB_HUMANTF -> target geneTRANSFAC
ELK1_HUMANACTB_HUMANTF -> target geneTRANSFAC
ELK4_HUMANACTB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ACTB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005856cytoskeletonTAScellular_component
GO:0005829cytosolIEAcellular_component
GO:0006928cellular component movementTASbiological_process
GO:0030424axonIEAcellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0006457protein foldingTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0034332adherens junction organizationTASbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0030957Tat protein bindingIPImolecular_function
GO:0070688MLL5-L complexIDAcellular_component
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0034329cell junction assemblyTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0019894kinesin bindingIPImolecular_function
GO:0050998nitric-oxide synthase bindingIPImolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0035267NuA4 histone acetyltransferase complexIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043234protein complexIEAcellular_component