Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZHX2_HUMAN
Description:zinc fingers and homeoboxes 2 [Source:HGNC Symbol;Acc:18513]
Location:chr8 q24.13
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T566RLRVEtKLSRRHomeoboxPhosphoSitePlus
T411KRPLVtPQAAPPhosphoSitePlus
T37EKGIGtPQPDVHPRD
T222RLVTDtAEILSPhosphoSitePlus
Y470DDAEVyRLIEVADPrib_exo_Tox; HomeoboxPhosphoSitePlus
S775DRSEGsSRDGQPhosphoSitePlus
Y267LNTTKyNSALDPhosphoSitePlus
T713VARKAtKPMAEPhosphoSitePlus
T220TARLVtDTAEIPhosphoSitePlus
Y705ADDHGyDAVARPhosphoSitePlus
S569VETKLsRREIDHomeoboxPhosphoSitePlus
T344QSVPPtITVLPPhosphoSitePlus; HPRD
S719KPMAEsPKNGGPhosphoSitePlus
S442PLTPAsDRKKTPhosphoSitePlus
S586RKLRDsMEQAVPhosphoSitePlus
S7ASKRKsTTPCMPhosphoSitePlus
T439ANPPLtPASDRPhosphoSitePlus
T8SKRKStTPCMVPhosphoSitePlus
T207KPEEItPENHVPhosphoSitePlus
T9KRKSTtPCMVRPhosphoSitePlus
T215NHVEGtARLVTPhosphoSitePlus
T355AQLAPtKVTQPPhosphoSitePlus; HPRD
S776RSEGSsRDGQGPhosphoSitePlus
S269TTKYNsALDTNPhosphoSitePlus

Dephosphorylation site
ZHX2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314709N116KBIOMARTGastric Cancer21930507, 21930502
ENSP00000314709G779SBIOMARTGastric Cancer21930507, 21930502
ENSP00000314709G601ATCGAOvarian Cancer21720365, 18772890
ENSP00000314709S54FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ZHX2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZHX2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZHX2_HUMANMP2K1_HUMANkinase -> substrateRegPhos
ZHX2_HUMANMYC_HUMANkinase -> substrateRegPhos
ZHX2_HUMANMP2K2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
ZHX2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0006402mRNA catabolic processIEAbiological_process


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