| UniProt/SwissProt ID: | XRCC5_HUMAN |
| Description: | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [Source:HGNC Symbol;Acc:12833] |
| Location: | chr2 q35 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y295 | QKETVyCLNDD | Ku | PhosphoSitePlus |
| S258 | IGSNLsIRIAA | Ku | PhosphoSitePlus |
| S712 | PKDKPsGDTAA | HPRD | |
| T524 | PAEVTtKSQIP | Ku_C | PhosphoSitePlus |
| S145 | SRFSKsQLDII | Ku_N | PhosphoSitePlus |
| Y416 | HIKHNyECLVY | Ku | PhosphoSitePlus |
| S437 | QYMFSsLKNSK | Ku | PhosphoSitePlus |
| S577 | GGAHFsVSSLA | PhosphoSitePlus; phosphoELM | |
| S255 | RLTIGsNLSIR | Ku | PhosphoSitePlus |
| T629 | LDTNEtPYFMK | PhosphoSitePlus | |
| T535 | LSKIKtLFPLI | Ku_C | PhosphoSitePlus |
| S379 | AVALSsLIHAL | HPRD | |
| T715 | KPSGDtAAVFE | PhosphoSitePlus; phosphoELM | |
| T523 | PPAEVtTKSQI | Ku_C | PhosphoSitePlus |
| S378 | AAVALsSLIHA | HPRD | |
| S585 | SLAEGsVTSVG | PhosphoSitePlus | |
| S102 | KIQPGsQQADF | Ku_N | PhosphoSitePlus |
| T39 | AKKVItMFVQR | Ku_N | PhosphoSitePlus |
| S580 | HFSVSsLAEGS | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| XRCC5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000375977 | H411D | COSMIC | Lung Cancer | 20668451 | ENSP00000375977 | E570* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000375978 | E570* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000375978 | Q104* | COSMIC | Renal Cancer | ENSP00000375977 | Q104* | COSMIC | Renal Cancer | ENSP00000375978 | I412V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000375978 | H411D | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000375977 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.59 | 12096126 | ENSP00000375977 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.62 | 12096126 | ENSP00000375977 | Prostate Cancer | Treatment (none vs. bicalutamide treatment) | cell line | Down | 0.82 | 17152098 | ENSP00000375977 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.49 | 19142970 | ENSP00000375977 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 18571811 | ENSP00000375977 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Down | 20417730 | ENSP00000375977 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| XRCC5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK3_HUMAN | XRCC5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | XRCC5_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03450 | Non-homologous end-joining |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006303 | double-strand break repair via nonhomologous end j | TAS | biological_process |
| GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | IMP | molecular_function |
| GO:0003691 | double-stranded telomeric DNA binding | IDA | molecular_function |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0003690 | double-stranded DNA binding | TAS | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IEA | molecular_function |
| GO:0006302 | double-strand break repair | IEA | biological_process |
| GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0070419 | nonhomologous end joining complex | IDA | cellular_component |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0060218 | hematopoietic stem cell differentiation | IEA | biological_process |
| GO:0050769 | positive regulation of neurogenesis | IEA | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0043564 | Ku70:Ku80 complex | IDA | cellular_component |
| GO:0000723 | telomere maintenance | TAS | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000783 | nuclear telomere cap complex | TAS | cellular_component |
| GO:0042162 | telomeric DNA binding | IDA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0016817 | hydrolase activity, acting on acid anhydrides | IEA | molecular_function |