Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WNT4_HUMAN
Description:wingless-type MMTV integration site family, member 4 [Source:HGNC Symbol;Acc:12783]
Location:chr1 p36.12
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T295GTRGRtCNKTSwntPhosphoSitePlus
T106VVTQGtREAAFwntPhosphoSitePlus
Y113EAAFVyAISSAwntPhosphoSitePlus
S130TRACSsGELEKwntPhosphoSitePlus
S66LEVMDsVRRGAwntPhosphoSitePlus

Dephosphorylation site
WNT4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000290167R107WCOSMICOvarian Cancer21720365

Differential expressed protein
WNT4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WNT4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT4_HUMANFZD6_HUMANligand -> receptorHPMR
WNT4_HUMANFZD2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma
hsa04340Hedgehog signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneIBAcellular_component
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0061205paramesonephric duct developmentIMPbiological_process
GO:0010894negative regulation of steroid biosynthetic procesIDAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0072273metanephric nephron morphogenesisIEAbiological_process
GO:0001656metanephros developmentIBAbiological_process
GO:0001838embryonic epithelial tube formationIEAbiological_process
GO:0018345protein palmitoylationIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0042445hormone metabolic processIEAbiological_process
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process
GO:0009798axis specificationIBAbiological_process
GO:2000066positive regulation of cortisol biosynthetic proceIDAbiological_process
GO:0007548sex differentiationIEAbiological_process
GO:0061369negative regulation of testicular blood vessel morIMPbiological_process
GO:0010629negative regulation of gene expressionIDAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0033077T cell differentiation in thymusIBAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007276gamete generationIEAbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0045669positive regulation of osteoblast differentiationIDAbiological_process
GO:0090002establishment of protein localization to plasma meIDAbiological_process
GO:0006702androgen biosynthetic processIDAbiological_process
GO:2000019negative regulation of male gonad developmentIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0030237female sex determinationIMPbiological_process
GO:0022407regulation of cell-cell adhesionIEAbiological_process
GO:0072033renal vesicle formationIEAbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:2000225negative regulation of testosterone biosynthetic pIEAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0030501positive regulation of bone mineralizationIDAbiological_process
GO:0001822kidney developmentIEPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005201extracellular matrix structural constituentNASmolecular_function
GO:0048599oocyte developmentIEAbiological_process
GO:0072164mesonephric tubule developmentIEAbiological_process
GO:0048018receptor agonist activityICmolecular_function
GO:0032349positive regulation of aldosterone biosynthetic prIDAbiological_process
GO:0008584male gonad developmentIMPbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0007267cell-cell signalingNASbiological_process
GO:0060748tertiary branching involved in mammary gland duct IEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0072034renal vesicle inductionIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0001889liver developmentIEPbiological_process
GO:0007492endoderm developmentIBAbiological_process
GO:0061180mammary gland epithelium developmentIEPbiological_process
GO:0009952anterior/posterior pattern specificationIBAbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0008585female gonad developmentIEAbiological_process
GO:0005109frizzled bindingIEAmolecular_function
GO:0071560cellular response to transforming growth factor beIEPbiological_process
GO:0045836positive regulation of meiosisIEAbiological_process
GO:0035567non-canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0072162metanephric mesenchymal cell differentiationNASbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0033080immature T cell proliferation in thymusIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIDAbiological_process
GO:0005794Golgi apparatusIBAcellular_component
GO:0038030non-canonical Wnt receptor signaling pathway via MIDAbiological_process
GO:0035239tube morphogenesisIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0060126somatotropin secreting cell differentiationIEAbiological_process
GO:0048856anatomical structure developmentIEAbiological_process
GO:0060129thyroid-stimulating hormone-secreting cell differeIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0001664G-protein coupled receptor bindingIBAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0030325adrenal gland developmentIEPbiological_process
GO:0060231mesenchymal to epithelial transitionIEAbiological_process
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0001823mesonephros developmentIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIEPbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0061184positive regulation of dermatome developmentIDAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process