Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FZD6_HUMAN
Description:frizzled family receptor 6 [Source:HGNC Symbol;Acc:4044]
Location:chr8 q22.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S606KADGAsTPRLRPhosphoSitePlus; HPRD; phosphoELM
T607ADGAStPRLREPhosphoSitePlus; HPRD; phosphoELM
S656RISPKsDITDTHPRD; phosphoELM
S626PAASIsRLSGEPhosphoSitePlus
S653SEGRIsPKSDIHPRD; phosphoELM
S624ASPAAsISRLSPhosphoSitePlus
S629SISRLsGEQVDPhosphoSitePlus
S620CGEPAsPAASIPhosphoSitePlus
T659PKSDItDTGLAHPRD; phosphoELM

Dephosphorylation site
FZD6_HUMAN do not have dephosphorylation site.

Mutation site
FZD6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351605Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
FZD6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT4_HUMANFZD6_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05217Basal cell carcinoma
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa05200Pathways in cancer
hsa04916Melanogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042472inner ear morphogenesisIBAbiological_process
GO:0033278cell proliferation in midbrainIEAbiological_process
GO:0042813Wnt-activated receptor activityIDAmolecular_function
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0001843neural tube closureIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0032589neuron projection membraneIBAcellular_component
GO:0007409axonogenesisIBAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0045177apical part of cellIBAcellular_component
GO:0005737cytoplasmIBAcellular_component
GO:0016327apicolateral plasma membraneIEAcellular_component
GO:0030901midbrain developmentIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0016327apicolateral plasma membraneIBAcellular_component
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0035567non-canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0007199G-protein coupled receptor signaling pathway couplIBAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0030168platelet activationIEAbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0005887integral to plasma membraneISScellular_component
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0001525angiogenesisIBAbiological_process
GO:0001736establishment of planar polarityIEAbiological_process
GO:0008406gonad developmentIBAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001736establishment of planar polarityIBAbiological_process
GO:0016020membraneIEAcellular_component
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0001843neural tube closureIBAbiological_process
GO:0033278cell proliferation in midbrainIBAbiological_process


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