| UniProt/SwissProt ID: | WIF1_HUMAN |
| Description: | WNT inhibitory factor 1 [Source:HGNC Symbol;Acc:18081] |
| Location: | chr12 q14.3 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T215 | EKALCtPRCMN | EGF | PhosphoSitePlus |
| T255 | CFNGGtCFYPG | EGF | PhosphoSitePlus |
| Dephosphorylation site |
| WIF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000286574 | I378S | COSMIC | Lung Cancer | ENSP00000286574 | G235E | COSMIC | Melanoma | 21499247 | ENSP00000286574 | K364R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000286574 | G235E | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| WIF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WIF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| WIF1_HUMAN | FZD10_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0045600 | positive regulation of fat cell differentiation | IEA | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |