Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VMAT2_HUMAN
Description:solute carrier family 18 (vesicular monoamine), member 2 [Source:HGNC Symbol;Acc:10935]
Location:chr10 q25.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S511GEDEEsESDCK2a2RegPhos
T286KGTPLtTLLKDMFS_1PhosphoSitePlus
S511GEDEEsEphosphoELM
S240GPPFGsVLYEFMFS_1; TMPhosphoSitePlus
S513DEESEsD____PhosphoSitePlus
T283ESQKGtPLTTLMFS_1PhosphoSitePlus
S511GEDEEsECK2_groupphosphoELM
S511GEDEEsECSNK1A1HPRD
S513DEESEsDCK2_groupRegPhos
S511GEDEEsESD__PhosphoSitePlus
S511GEDEEsECSNK2A2HPRD
S511GEDEEsECSNK2A1HPRD
S511GEDEEsESDCK2a1-rsRegPhos
S511GEDEEsECK1_groupphosphoELM
T287GTPLTtLLKDPMFS_1PhosphoSitePlus
S511GEDEEsESDCK2a1RegPhos
S511GEDEEsESDCK2_groupRegPhos
S513DEESEsDCK1_groupRegPhos
S513DEESECK2_groupphosphoELM
S513DEESEHPRD; phosphoELM
S511GEDEEsESDCK1_groupRegPhos
S511GEDEEsESDCK1aRegPhos
S513DEESECK1_groupphosphoELM
S279RVQPEsQKGTPMFS_1PhosphoSitePlus

Dephosphorylation site
VMAT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000298472V332IBIOMARTBrain Cancer21930507, 21930502

Differential expressed protein
VMAT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VMAT2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANVMAT2_HUMANkinase -> substrateHPRD
CSK22_HUMANVMAT2_HUMANkinase -> substrateHPRD
KC1A_HUMANVMAT2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa05012Parkinson's disease
hsa05034Alcoholism
hsa04721Synaptic vesicle cycle
hsa05030Cocaine addiction
hsa05031Amphetamine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030073insulin secretionIEAbiological_process
GO:0008021synaptic vesicleIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0030672synaptic vesicle membraneIEAcellular_component
GO:0009636response to toxinIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0042220response to cocaineIEAbiological_process
GO:0031045dense core granuleIEAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0010043response to zinc ionIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0031072heat shock protein bindingIEAmolecular_function
GO:0006836neurotransmitter transportIEAbiological_process
GO:0010038response to metal ionIEAbiological_process
GO:0032456endocytic recyclingIEAbiological_process
GO:0070083clathrin-sculpted monoamine transport vesicle membTAScellular_component
GO:0006837serotonin transportIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0001975response to amphetamineIEAbiological_process
GO:0015222serotonin transmembrane transporter activityIEAmolecular_function
GO:0007269neurotransmitter secretionTASbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0015844monoamine transportIEAbiological_process
GO:0051589negative regulation of neurotransmitter transportIEAbiological_process
GO:0042995cell projectionIEAcellular_component
GO:0042594response to starvationIEAbiological_process
GO:0015844monoamine transportTASbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0009791post-embryonic developmentIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0035690cellular response to drugIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0016265deathIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0009635response to herbicideIEAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0022857transmembrane transporter activityIEAmolecular_function
GO:0043679axon terminusIEAcellular_component
GO:0008504monoamine transmembrane transporter activityTASmolecular_function
GO:0005275amine transmembrane transporter activityIEAmolecular_function
GO:0016020membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0071242cellular response to ammonium ionIEAbiological_process


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