UniProt/SwissProt ID: | VDAC1_HUMAN |
Description: | voltage-dependent anion channel 1 [Source:HGNC Symbol;Acc:12669] |
Location: | chr5 q31.1 |
Node attribute: | substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S101 | KLTFDsSFSPN | TM; Porin_3 | PhosphoSitePlus |
T98 | RGLKLtFDSSF | HPRD | |
Y195 | FGGSIyQKVNK | HPRD | |
T107 | SFSPNtGKKNA | Porin_3 | PhosphoSitePlus |
T165 | AKSRVtQSNFA | TM; Porin_3 | PhosphoSitePlus |
S193 | TEFGGsIYQKV | TM; Porin_3 | PhosphoSitePlus |
Y225 | GIAAKyQIDPD | TM; Porin_3 | PhosphoSitePlus |
Y67 | YRWTEyGLTFT | Porin_3 | PhosphoSitePlus |
Y173 | NFAVGyKTDEF | HPRD | |
S102 | LTFDSsFSPNT | HPRD | |
Y62 | SLETKyRWTEY | TM; Porin_3 | PhosphoSitePlus |
S241 | KVNNSsLIGLG | Porin_3 | PhosphoSitePlus |
T107 | SFSPNtGKKNA | HPRD | |
S101 | KLTFDsSFSPN | HPRD; phosphoELM | |
Y195 | FGGSIyQKVNK | TM; Porin_3 | PhosphoSitePlus |
Y22 | VFTKGyGFGLI | Porin_3 | PhosphoSitePlus |
Y247 | LIGLGyTQTLK | TM; Porin_3 | PhosphoSitePlus |
S104 | FDSSFsPNTGK | TM; Porin_3 | PhosphoSitePlus |
S43 | GLEFTsSGSAN | TM; Porin_3 | PhosphoSitePlus |
T19 | ARDVFtKGYGF | Porin_3 | PhosphoSitePlus |
S13 | ADLGKsARDVF | Porin_3 | PhosphoSitePlus |
S104 | FDSSFsPNTGK | HPRD; phosphoELM | |
S240 | AKVNNsSLIGL | Porin_3 | PhosphoSitePlus |
Y67 | YRWTEyGLTFT | HPRD; phosphoELM | |
Dephosphorylation site |
VDAC1_HUMAN do not have dephosphorylation site. |
Mutation site |
VDAC1_HUMAN do not have mutation site. |
Differential expressed protein |
Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
---|---|---|---|---|---|---|
ENSP00000378487 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 3.8 | 16788983 |
ENSP00000378487 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.61 | 20052998 |
ENSP00000378487 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.47 | 20052998 |
ENSP00000378487 | Breast Cancer | Metastasis | cell line | Down | 0.78 | 20052998 |
ENSP00000378487 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Up | 1.3 | 20417730 |
ENSP00000378487 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Up | 2 | 19422301 |
Hyperphosphorylation site |
VDAC1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
MK08_HUMAN | VDAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
Function Annotation |
KEGG Pathway |
VDAC1_HUMAN is not in KEGG pathway. |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0055085 | transmembrane transport | IEA | biological_process |
GO:0046930 | pore complex | TAS | cellular_component |
GO:0015288 | porin activity | IEA | molecular_function |
GO:0008308 | voltage-gated anion channel activity | IEA | molecular_function |
GO:0005739 | mitochondrion | IEA | cellular_component |
GO:0005739 | mitochondrion | TAS | cellular_component |
GO:0007612 | learning | IEA | biological_process |
GO:0007268 | synaptic transmission | IEA | biological_process |
GO:0006820 | anion transport | TAS | biological_process |
GO:0016020 | membrane | ISS | cellular_component |
GO:0005743 | mitochondrial inner membrane | IEA | cellular_component |
GO:0042645 | mitochondrial nucleoid | IDA | cellular_component |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0005741 | mitochondrial outer membrane | IEA | cellular_component |
GO:0001662 | behavioral fear response | IEA | biological_process |
GO:0016020 | membrane | IEA | cellular_component |
GO:0006915 | apoptotic process | TAS | biological_process |
GO:0019048 | virus-host interaction | IEA | biological_process |
GO:0007270 | neuron-neuron synaptic transmission | IEA | biological_process |
GO:0005886 | plasma membrane | IEA | cellular_component |