| UniProt/SwissProt ID: | V1BR_HUMAN |
| Description: | arginine vasopressin receptor 1B [Source:HGNC Symbol;Acc:896] |
| Location: | chrHG1293_PATCH q32. |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S371 | RLSDGsLSSRH | PhosphoSitePlus | |
| Y338 | CNPWIyMGFNS | HPRD | |
| S267 | LPSRVsSINTI | 7tm_1 | PhosphoSitePlus |
| T258 | STLAAtTRGLP | 7tm_1 | PhosphoSitePlus |
| T271 | VSSINtISRAK | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| V1BR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356094 | A188E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356094 | A188E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356094 | I163N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356094 | T129M | COSMIC | Intestines Cancer | 17932254 | ENSP00000356094 | S299fs*82 | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| V1BR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| V1BR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEU2_HUMAN | V1BR_HUMAN | ligand -> receptor | HPMR |
| V1BR_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| V1BR_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005768 | endosome | TAS | cellular_component |
| GO:0005000 | vasopressin receptor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005080 | protein kinase C binding | TAS | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0001992 | regulation of systemic arterial blood pressure by | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |