| UniProt/SwissProt ID: | ULK3_HUMAN |
| Description: | unc-51-like kinase 3 (C. elegans) [Source:HGNC Symbol;Acc:19703] |
| Location: | chr15 q24.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S176 | HVLRGsPLYMA | Pkinase | PhosphoSitePlus |
| S176 | HVLRGsPLYMA | HPRD | |
| S165 | FAQHMsPWDEK | HPRD | |
| S219 | ASRSFsELEEK | Pkinase | PhosphoSitePlus |
| S300 | DQEGDsAAALS | MIT | PhosphoSitePlus |
| S350 | KAIVSsSNQAL | PhosphoSitePlus | |
| S384 | ALEVAsAAMAK | MIT | PhosphoSitePlus |
| S464 | EGLSEsVRSSC | PhosphoSitePlus | |
| S165 | FAQHMsPWDEK | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| ULK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000400312 | V75G | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ULK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ULK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ULK3_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MTOR_HUMAN | ULK3_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04140 | Regulation of autophagy |
| hsa04150 | mTOR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000407 | pre-autophagosomal structure | TAS | cellular_component |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0045879 | negative regulation of smoothened signaling pathwa | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006914 | autophagy | TAS | biological_process |
| GO:0045880 | positive regulation of smoothened signaling pathwa | IDA | biological_process |
| GO:0090398 | cellular senescence | TAS | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |