| UniProt/SwissProt ID: | UBF1_HUMAN |
| Description: | upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:12511] |
| Location: | chr17 q21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y456 | KKKAKyKAREA | HMG_box | PhosphoSitePlus |
| S638 | WVKSLsPQDRA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S412 | PKRPVsAMFIF | HMG_box | PhosphoSitePlus; SysPTM |
| S23 | GQDRWsQEDML | PhosphoSitePlus; HPRD | |
| S273 | PELNIsEEGIT | PhosphoSitePlus; HPRD | |
| Y150 | ILSKKyKELPE | HMG_box | PhosphoSitePlus |
| T117 | PKKPLtPYFRF | Erk2(MAPK1 | RegPhos |
| S412 | PKRPVsAMFIF | HPRD; phosphoELM; SysPTM | |
| S602 | MVEIGsRWQRI | HMG_box | PhosphoSitePlus |
| T117 | PKKPLtPYFRF | Erk2 | RegPhos |
| S495 | EIWQQsVIGDY | PhosphoSitePlus; HPRD; phosphoELM | |
| S520 | PAATNsSKKMK | HPRD | |
| T201 | PEKPKtPQQLW | Erk2 | RegPhos; SysPTM |
| S447 | GKLPEsPKRAE | HPRD | |
| S236 | PELNIsEEGIT | HPRD | |
| S458 | EIWQQsVIGDY | HPRD | |
| S666 | GPNPKsSRTTL | HPRD | |
| T201 | PEKPKtPQQLW | HMG_box | PhosphoSitePlus; SysPTM |
| S389 | KKQATsPASKK | PhosphoSitePlus | |
| T388 | NKKQAtSPASK | PhosphoSitePlus | |
| T201 | PEKPKtPQQLW | HPRD; phosphoELM; SysPTM | |
| S392 | ATSPAsKKPAQ | PhosphoSitePlus | |
| T117 | PKKPLtPYFRF | HMG_box | PhosphoSitePlus |
| S389 | KKQATsPASKK | CDK2 | HPRD; phosphoELM; RegPhos |
| Y648 | AAYKEyISNKR | PhosphoSitePlus | |
| T117 | PKKPLtPYFRF | Erk1 | RegPhos |
| S557 | PAATNsSKKMK | HPRD | |
| S147 | LTKILsKKYKE | HMG_box | PhosphoSitePlus |
| S601 | WVKSLsPQDRA | HPRD | |
| S484 | GKLPEsPKRAE | CDK4 | phosphoELM; RegPhos; SysPTM |
| S484 | GKLPEsPKRAE | CDK2 | HPRD; RegPhos; SysPTM |
| T201 | PEKPKtPQQLW | MAPK1 | HPRD; phosphoELM; SysPTM |
| T201 | PEKPKtPQQLW | MAPK3 | HPRD; phosphoELM; SysPTM |
| S484 | GKLPEsPKRAE | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| T201 | PEKPKtPQQLW | Erk2(MAPK1 | RegPhos; SysPTM |
| S412 | MWNDLsEKKKA | HPRD; SysPTM | |
| S655 | SNKRKsMTKLR | PhosphoSitePlus | |
| T201 | PEKPKtPQQLW | Erk1(MAPK3 | RegPhos; SysPTM |
| T201 | PEKPKtPQQLW | Erk1 | RegPhos; SysPTM |
| S375 | PKRPVsAMFIF | HPRD | |
| S44 | PSNDSsKFKTT | PhosphoSitePlus | |
| Y207 | PQQLWyTHEKK | HMG_box | PhosphoSitePlus |
| S449 | MWNDLsEKKKA | HMG_box | PhosphoSitePlus |
| T117 | PKKPLtPYFRF | Erk1(MAPK3 | RegPhos |
| S449 | MWNDLsEKKKA | HPRD | |
| T117 | PKKPLtPYFRF | MAPK3 | HPRD; phosphoELM |
| T117 | PKKPLtPYFRF | MAPK1 | HPRD; phosphoELM |
| S629 | GPNPKsSRTTL | HPRD | |
| Dephosphorylation site |
| UBF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000302640 | D689E | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| UBF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| UBF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | UBF1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK01_HUMAN | UBF1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK03_HUMAN | UBF1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| CDK2_HUMAN | UBF1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | UBF1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| UBF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045943 | positive regulation of transcription from RNA poly | ISS | biological_process |
| GO:0005730 | nucleolus | ISS | cellular_component |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006363 | termination of RNA polymerase I transcription | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006360 | transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0006362 | transcription elongation from RNA polymerase I pro | TAS | biological_process |
| GO:0001832 | blastocyst growth | IEA | biological_process |
| GO:0006356 | regulation of transcription from RNA polymerase I | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0010468 | regulation of gene expression | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0007566 | embryo implantation | IEA | biological_process |
| GO:0006361 | transcription initiation from RNA polymerase I pro | TAS | biological_process |