Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UBF1_HUMAN
Description:upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:12511]
Location:chr17 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y456KKKAKyKAREAHMG_boxPhosphoSitePlus
S638WVKSLsPQDRAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S412PKRPVsAMFIFHMG_boxPhosphoSitePlus; SysPTM
S23GQDRWsQEDMLPhosphoSitePlus; HPRD
S273PELNIsEEGITPhosphoSitePlus; HPRD
Y150ILSKKyKELPEHMG_boxPhosphoSitePlus
T117PKKPLtPYFRFErk2(MAPK1RegPhos
S412PKRPVsAMFIFHPRD; phosphoELM; SysPTM
S602MVEIGsRWQRIHMG_boxPhosphoSitePlus
T117PKKPLtPYFRFErk2RegPhos
S495EIWQQsVIGDYPhosphoSitePlus; HPRD; phosphoELM
S520PAATNsSKKMKHPRD
T201PEKPKtPQQLWErk2RegPhos; SysPTM
S447GKLPEsPKRAEHPRD
S236PELNIsEEGITHPRD
S458EIWQQsVIGDYHPRD
S666GPNPKsSRTTLHPRD
T201PEKPKtPQQLWHMG_boxPhosphoSitePlus; SysPTM
S389KKQATsPASKKPhosphoSitePlus
T388NKKQAtSPASKPhosphoSitePlus
T201PEKPKtPQQLWHPRD; phosphoELM; SysPTM
S392ATSPAsKKPAQPhosphoSitePlus
T117PKKPLtPYFRFHMG_boxPhosphoSitePlus
S389KKQATsPASKKCDK2HPRD; phosphoELM; RegPhos
Y648AAYKEyISNKRPhosphoSitePlus
T117PKKPLtPYFRFErk1RegPhos
S557PAATNsSKKMKHPRD
S147LTKILsKKYKEHMG_boxPhosphoSitePlus
S601WVKSLsPQDRAHPRD
S484GKLPEsPKRAECDK4phosphoELM; RegPhos; SysPTM
S484GKLPEsPKRAECDK2HPRD; RegPhos; SysPTM
T201PEKPKtPQQLWMAPK1HPRD; phosphoELM; SysPTM
T201PEKPKtPQQLWMAPK3HPRD; phosphoELM; SysPTM
S484GKLPEsPKRAEPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T201PEKPKtPQQLWErk2(MAPK1RegPhos; SysPTM
S412MWNDLsEKKKAHPRD; SysPTM
S655SNKRKsMTKLRPhosphoSitePlus
T201PEKPKtPQQLWErk1(MAPK3RegPhos; SysPTM
T201PEKPKtPQQLWErk1RegPhos; SysPTM
S375PKRPVsAMFIFHPRD
S44PSNDSsKFKTTPhosphoSitePlus
Y207PQQLWyTHEKKHMG_boxPhosphoSitePlus
S449MWNDLsEKKKAHMG_boxPhosphoSitePlus
T117PKKPLtPYFRFErk1(MAPK3RegPhos
S449MWNDLsEKKKAHPRD
T117PKKPLtPYFRFMAPK3HPRD; phosphoELM
T117PKKPLtPYFRFMAPK1HPRD; phosphoELM
S629GPNPKsSRTTLHPRD

Dephosphorylation site
UBF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302640D689ECOSMICHead and Neck Cancer21798893

Differential expressed protein
UBF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
UBF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANUBF1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK01_HUMANUBF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANUBF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CDK2_HUMANUBF1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANUBF1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
UBF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045943positive regulation of transcription from RNA polyISSbiological_process
GO:0005730nucleolusISScellular_component
GO:0005488bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0006362transcription elongation from RNA polymerase I proTASbiological_process
GO:0001832blastocyst growthIEAbiological_process
GO:0006356regulation of transcription from RNA polymerase I TASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007566embryo implantationIEAbiological_process
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process


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